| Status | 已發表Published |
| Role of IGF-1R Signaling in the Development Melanoma | |
Zheng, W. 
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| 2015-03-22 | |
| Source Publication | BIT’S6THAnnual World Congress of Neurotalk
 |
| Abstract | Uveal melanoma is one of the most common malignant tumors in the adult eyes.Despite years of investigation, the pathogenesis of tumor is still unclear. Previous studies indicate that the growth factor IGF-1 is closely related to the development and progression of uveal melanoma. It is well known that PI3K/akt/foxO and MAPK signal pathways are two major pathways mediating the biological roles of IR/IGF-1R, thus, it is interesting to investigate whether the alterations of IR/IGF-IR signaling are involved in the progression of uveal melanoma. In this research, we aim to investigate the roles of IGF-1 on the growth, migration and invasion of IGF-1, and MTT assay, CCK-8 analysis, scratch adhesion test and trasswell migration/invasion assay were performed 24h after the treatment to study the biological roles of IGF-1 on uveal melanoma cells. Our results showed that IGF-1, in a dose-dependent manner, increased the viability, migration and invasion of uveal melanoma cells.Western blot ananlysis showed that treatment with IGF-1 increased the phosphorylation of Akt and FOXO3a , while the PI3K/AKT signaling pathway inhibitor LY294002 blocked the roles of IGF-1 on the IGF-1 can promote the growth, migration and invasion of uveal melanoma cells |
| Keyword | IGF-1 PI3K/akt/foxO MAPK IR/IGF-1R |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 19189 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Zheng, W.. Role of IGF-1R Signaling in the Development Melanoma[C], 2015. |
| APA | Zheng, W..(2015). Role of IGF-1R Signaling in the Development Melanoma. BIT’S6THAnnual World Congress of Neurotalk. |
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