| Status | 已發表Published |
| BDNF Induce the expression of Synapsin I in Primary Cultured Cortical Neurons | |
Zheng, W. 
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| 2015-03-22 | |
| Source Publication | BIT’S6THAnnual World Congress of Neurotalk
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| Abstract | Normal synapse struture and functions are essential for learning and remembering.BDNF is a major neurotrophic factor with an important role in the development of synapse formation. To study the role of BDNF in the formation of synapse, we investigated the effect of BDNF on the expression of synapse I in primary cultured cortical neurons. The effect is time- and concentration-dependent with the maximal effect of BDNF at 100ng/ml and 6 h respectively. Western blot with phospho-antibodies for various kinases showed that BDNF activated the MAPK and the PI3K pathways in these culture neurons. Blockage of the activation of PI3K pathway with PI3K specific inhibitor LY294002 attenuated the expression of synapse I induced by BDNF, while less effect was seen for the MAPK pathway inhibitoe PD98059. These results put together indicate that BDNF is able to induce the expression of synapse I in primary neurons via the PI3K pathway |
| Keyword | BDNF synapse I MAPK PI3K primary neurons |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 19190 |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | Zheng, W. |
| Recommended Citation GB/T 7714 | Zheng, W.. BDNF Induce the expression of Synapsin I in Primary Cultured Cortical Neurons[C], 2015. |
| APA | Zheng, W..(2015). BDNF Induce the expression of Synapsin I in Primary Cultured Cortical Neurons. BIT’S6THAnnual World Congress of Neurotalk. |
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