| Residential College | false |
| Patent Number | 202210347227.8 |
| Status | 申請中 Pending |
| β-环糊精介导的免疫细胞-载药脂质体偶连体在抗动脉粥样硬化中的应用 | |
| 2022-04-01 | |
| Application Date | 2022-04-01 |
WANG RUIBING ; 高成; 李铭源
| |
| Country | 中国 |
| Subtype | 发明专利Invention |
| Abstract | 本发明公开了β-环糊精介导的免疫细胞-载药脂质体偶连体在抗动脉粥样硬化中的应用，涉及超分子化学、超分子材料和细胞制剂技术领域。药效学实验证实β-环糊精介导的免疫细胞-载药脂质体搭便车式给药系统，作为药物“内应式”载体，在体内发挥类似于“间谍”样的作用，响应斑块部位的炎性信号，实现自主引导的靶向递送效果，增强药物在动脉板块部位的积累，同时创造性的发现β-环糊精不仅作为主体分子用于构建免疫细胞-载药脂质体，还可结合斑块中胆固醇，促进其溶解，降低斑块面积，与载药脂质体实现协同抗动脉粥样硬化疗效，具有良好应用前景。 |
| Language | 中文Chinese |
| Document Type | Patent |
| Collection | Institute of Chinese Medical Sciences |
| Affiliation | State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | WANG RUIBING,高成,李铭源. β-环糊精介导的免疫细胞-载药脂质体偶连体在抗动脉粥样硬化中的应用. 202210347227.8[P]. 2022-04-01. |
| APA | WANG RUIBING., 高成., & 李铭源 (2022-04-01). β-环糊精介导的免疫细胞-载药脂质体偶连体在抗动脉粥样硬化中的应用. |
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