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An antibacterial hemostatic AuNPs@corn stalk/chitin composite sponge with shape recovery for promoting wound healing
Zheng, Lu1; Gu, Bin1; Li, Shanshan1; Luo, Bichong1; Wen, Yuming1; Chen, Meiwan2; Li, Xiaoyun1; Zha, Zhengang3; Zhang, Huan Tian3; Wang, Xiaoying1
2022-11-15
Source PublicationCarbohydrate Polymers
ISSN0144-8617
Volume296Pages:119924
Abstract

The development of shape-memory sponge dressings with functions, such as hemostasis, antibacterial activity, and wound healing, is of great significance in clinical applications. Herein, a novel AuNPs@corn stalk/chitin composite sponge (CCAu) was fabricated by crosslinking the chitin matrix with corn stalk-embedded gold nanoparticles (AuNPs). The addition of AuNPs@corn stalk gave the porous chitin sponge shape-recovery ability with improved softness, porosity, and water absorption. Correspondingly, the composite sponge showed better hemostatic effects than commercial PVF sponges. The photothermal effect of AuNPs endowed the composite sponge with excellent antibacterial activity. In addition, the wound treated with composite sponge containing antioxidant AuNPs exhibited a significantly faster wound healing rate (reaching 41.6 % on day 3) than the CH (33.2 %) and control (12.6 %) group through promoting cell migration, angiogenesis and collagen deposition. Therefore, the multifunctional composite sponge with great biocompatibility in this work provides a potential strategy for wound healing.

KeywordChitin Sponge Aunps@corn Stalk Shape-recovery Photothermal Antibacterial Effect Hemostatic Sponge Wound Healing
DOI10.1016/j.carbpol.2022.119924
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000843937700002
PublisherELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Scopus ID2-s2.0-85135389160
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionTHE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Institute of Chinese Medical Sciences
Corresponding AuthorLi, Xiaoyun; Zhang, Huan Tian
Affiliation1.State Key Laboratory of Pulp & Paper Engineering, South China University of Technology, Guangzhou, 510640, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China
3.Department of Bone and Joint Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, China
Recommended Citation
GB/T 7714
Zheng, Lu,Gu, Bin,Li, Shanshan,et al. An antibacterial hemostatic AuNPs@corn stalk/chitin composite sponge with shape recovery for promoting wound healing[J]. Carbohydrate Polymers, 2022, 296, 119924.
APA Zheng, Lu., Gu, Bin., Li, Shanshan., Luo, Bichong., Wen, Yuming., Chen, Meiwan., Li, Xiaoyun., Zha, Zhengang., Zhang, Huan Tian., & Wang, Xiaoying (2022). An antibacterial hemostatic AuNPs@corn stalk/chitin composite sponge with shape recovery for promoting wound healing. Carbohydrate Polymers, 296, 119924.
MLA Zheng, Lu,et al."An antibacterial hemostatic AuNPs@corn stalk/chitin composite sponge with shape recovery for promoting wound healing".Carbohydrate Polymers 296(2022):119924.
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