| Status | 即將出版Forthcoming |
| Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung" | |
| Lu, Yu Hui1,2,3; Ouyang, Shu Hua1,2,3; Weng, Jing Yu1,2,3; Liu, Pei1,4; Chen, Xin Xing1,2,3; Hiroshi, Kurihara1,2,3; Li, Yi Fang1,2,3; He, Rong Rong1,2,3 | |
| 2022-06-01 | |
| Source Publication | Yaoxue Xuebao
 |
| ISSN | 0513-4870 |
| Volume | 57Issue:6Pages:1649-1656 |
| Abstract | In this study, chronic emotional stress-induced H1N1 influenza susceptibility model was employed to simulate the states of "emotional stagnation" and "liver fire invading lung", and the protective effect of Qinggan Xiefei Fang on viral pneumonia was investigated. Survival rate and morbidity rate of mice were observed within 21 days after H1N1 infection, the symptoms of viral pneumonia and the level of phospholipid peroxidation were detected in lungs of mice after 6-day infection. The experimental results showed that Qinggan Xiefei Fang could alleviate the decline of survival rate and morbidity rate of mice caused by chronic constraint stress loaded with H1N1, inhibit the replication of H1N1 and the production of inflammatory factors, reduce the level of phospholipid peroxidation, and improve the symptoms of pneumonia in mice. The results also showed that compound-target network of Qinggan Xiefei Fang contained 171 compounds and 260 corresponding targets involved in the signaling pathway of oxidative stress, inflammation and immunity. All the above results indicate that Qinggan Xiefei Fang protecting influenza virus pneumonia was related to the regulation of oxidative stress. The animal experimental protocol has been reviewed and approved by Laboratory Animal Ethics Committee of Jinan University, in compliance with the Institutional Animal Care Guidelines. |
| Keyword | emotional stress influenza viral pneumonia oxidative stress phospholipid peroxidation Qinggan Xiefei Fang |
| DOI | 10.16438/j.0513-4870.2022-0254 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85133217463 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou, 510632, China 2.Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, 510632, China 3.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou, 510632, China 4.School of Pharmacy and State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, 999078, China |
| Recommended Citation GB/T 7714 | Lu, Yu Hui,Ouyang, Shu Hua,Weng, Jing Yu,et al. Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"[J]. Yaoxue Xuebao, 2022, 57(6), 1649-1656. |
| APA | Lu, Yu Hui., Ouyang, Shu Hua., Weng, Jing Yu., Liu, Pei., Chen, Xin Xing., Hiroshi, Kurihara., Li, Yi Fang., & He, Rong Rong (2022). Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung". Yaoxue Xuebao, 57(6), 1649-1656. |
| MLA | Lu, Yu Hui,et al."Effect of Qinggan Xiefei Fang on increasing susceptibility of influenza virus caused by "liver fire invading lung"".Yaoxue Xuebao 57.6(2022):1649-1656. |
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