| Residential College | false |
| Status | 即將出版Forthcoming |
| Association of DNA methylation and transcriptome reveals epigenetic etiology of heart failure | |
Lin, Zhongxiao1,2,3; Chang, Jishuo1,3; Li, Xinzhi2; Wang, Jianglin1; Wu, Xiaodan1; Liu, Xiaoyan2,4; Zhu, Yi Zhun2 ; Yu, Xi Yong1,3
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| 2022-02-01 | |
| Source Publication | Functional and Integrative Genomics
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| ISSN | 1438-793X |
| Volume | 22Issue:1Pages:89-112 |
| Abstract | Epigenetic modifications viz. DNA methylation, histone modifications, and RNA-based alterations play a crucial role in the development of cardiovascular diseases. In this study, we investigated DNA methylation with an aim to reveal the epigenetic etiology of heart failure. Sprague–Dawley rats surviving myocardial infarction developed acute heart failure in 1 week. Genomic DNA methylation changes were profiled by bisulfite sequencing, and gene expression levels were analyzed by RNA-seq in failing and sham-operation hearts. A total of 3480 differentially methylated genes in the promoter regions including transcriptional start site and 1934 transcriptome-altered genes were identified in the defected hearts. Common differential genes were enriched by the gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway, and protein–protein interaction for HF phenotypes. Among these, Mettl11b, HDAC3, HDAC11, ubiquitination-related genes, and snoRNAs are new epigenetic classifiers that had not been reported yet, which may be important regulators in HF. |
| Keyword | Dna Methylation Epigenetic Heart Failure Promoter Transcriptome |
| DOI | 10.1007/s10142-021-00813-9 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| WOS Research Area | Genetics & Heredity |
| WOS Subject | Genetics & Heredity |
| WOS ID | WOS:000727130900001 |
| Publisher | SPRINGER HEIDELBERGTIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY |
| Scopus ID | 2-s2.0-85120603940 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Corresponding Author | Zhu, Yi Zhun; Yu, Xi Yong |
| Affiliation | 1.Key Laboratory of Molecular Target and Clinical Pharmacology and National Key Laboratory of Respiratory Diseases, School of Pharmaceutic Sciences and Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, China 2.China State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macao 3.South China Center for Drug Clinical Evaluation and Guangzhou Medical University New Drug Research and Development Co., Ltd, Guangzhou, 511436, China 4.Huangpu Branch, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, No. 58, Pu Yu Dong Road, Shanghai, 200011, China |
| First Author Affilication | University of Macau |
| Corresponding Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Lin, Zhongxiao,Chang, Jishuo,Li, Xinzhi,et al. Association of DNA methylation and transcriptome reveals epigenetic etiology of heart failure[J]. Functional and Integrative Genomics, 2022, 22(1), 89-112. |
| APA | Lin, Zhongxiao., Chang, Jishuo., Li, Xinzhi., Wang, Jianglin., Wu, Xiaodan., Liu, Xiaoyan., Zhu, Yi Zhun., & Yu, Xi Yong (2022). Association of DNA methylation and transcriptome reveals epigenetic etiology of heart failure. Functional and Integrative Genomics, 22(1), 89-112. |
| MLA | Lin, Zhongxiao,et al."Association of DNA methylation and transcriptome reveals epigenetic etiology of heart failure".Functional and Integrative Genomics 22.1(2022):89-112. |
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