Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer

doi:10.1016/j.ejphar.2022.175120

Residential College	false
Status	已發表Published
	Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer
	Hu, Shujian 1; Ma, Wantong 1; Wang, Junyi 2; Ma, Yunhao 1; Zhou, Zhongkun 1; Zhang, Rentao 1; Du, Kangjia 1; Zhang, Hao 1; Sun, Mengze 1; Jiang, Xinrong 1; Tu, Hongyuan 1; Tang, Xiaoliang 3; Yao, Xiaojun 4; Chen, Peng 1
	2022-08-05
Source Publication	European Journal of Pharmacology
ISSN	0014-2999
Volume	928
Abstract	1H-imidazole [4,5-f][1,10] phenanthroline is a promising chemical structure for cancer treatment. Herein, we synthesized a novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative named IPM714 and found it exhibited selectively colorectal cancer (CRC) cells inhibitory activities, with half maximal inhibitory concentration (IC) of 1.74 μM and 2 μM in HCT116 cells and SW480 cells, respectively. The present study is intended to explore the cytotoxicity of IPM714 in cancer cells of various types and its anticancer mechanism in vitro. Cellular functional analyses indicated IPM714 can arrest HCT116 cell cycle in S phase and induce apoptosis in HCT116 and SW480 cells. Western blot and molecular docking showed that IPM714 may suppress PI3K/AKT/mTOR pathway to inhibit cell proliferation and regulate cell cycle as well as apoptosis. This study proved IPM714 to be a promising drug in CRC therapy.
Keyword	1h-imidazole [4,5-f][1,10] Phenanthroline Apoptosis Cell Cycle Colorectal Cancer Mtor
DOI	10.1016/j.ejphar.2022.175120
URL	View the original
Indexed By	SCIE
Language	英語English
WOS Research Area	Pharmacology & Pharmacy
WOS Subject	Pharmacology & Pharmacy
WOS ID	WOS:000827400600003
Publisher	ELSEVIERR, ADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
Scopus ID	2-s2.0-85132901956
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Corresponding Author	Chen, Peng
Affiliation	1.School of Pharmacy, Lanzhou University, Lanzhou, 199 Donggang West Road, 730000, China 2.College of Science and Technology, Wenzhou-Kean University, Wenzhou, 88 Daxue Road, 325060, China 3.College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 222 Tianshui South Road, 730000, China 4.Macau Institute for Applied Research in Medicine and Health, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Avenida Wai Long, Macao
Recommended Citation GB/T 7714	Hu, Shujian,Ma, Wantong,Wang, Junyi,et al. Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer[J]. European Journal of Pharmacology, 2022, 928.
APA	Hu, Shujian., Ma, Wantong., Wang, Junyi., Ma, Yunhao., Zhou, Zhongkun., Zhang, Rentao., Du, Kangjia., Zhang, Hao., Sun, Mengze., Jiang, Xinrong., Tu, Hongyuan., Tang, Xiaoliang., Yao, Xiaojun., & Chen, Peng (2022). Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer. European Journal of Pharmacology, 928.
MLA	Hu, Shujian,et al."Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer".European Journal of Pharmacology 928(2022).

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh