| Status | 即將出版Forthcoming |
| Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/ Smad2 signalling pathway | |
| Li, Zhaoyi1,2; Chen, Keyuan1,2; Zhu, Yi Zhun1,2 | |
| 2022-11-01 | |
| Source Publication | PLoS ONE
 |
| Volume | 17Issue:11 November |
| Abstract | Cardiac fibrosis is a common cause of most cardiovascular diseases. Leonurine, an alkaloid from Herba leonuri, had been indicated to treat cardiovascular diseases due to its cardioprotective effects. Recently, pyroptosis, a programmed form of cell death that releases inflammatory factors, has been shown to play an important role in cardiovascular diseases, especially cardiac fibrosis. This study examined the novel mechanism by which leonurine protects against cardiac fibrosis. In rats with isoprenaline-induced cardiac fibrosis, leonurine inhibited the expression of proteins related to pyroptosis and improved cardiac fibrosis. In vitro, leonurine inhibited the expression of proteins related to pyroptosis and fibrosis. Additionally, leonurine regulated the TGF-β/Smad2 signalling pathway and inhibited pyroptosis to protect cardiomyocytes and improve cardiac fibrosis. Therefore, leonurine might improve cardiac fibrosis induced by isoprenaline by inhibiting pyroptosis via the TGF-β/Smad2 signalling pathway. |
| DOI | 10.1371/journal.pone.0275258 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85141890312 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Taipa, Macao 2.School of Pharmacy, Macau University of Science and Technology, Taipa, Macao |
| First Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Li, Zhaoyi,Chen, Keyuan,Zhu, Yi Zhun. Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/ Smad2 signalling pathway[J]. PLoS ONE, 2022, 17(11 November). |
| APA | Li, Zhaoyi., Chen, Keyuan., & Zhu, Yi Zhun (2022). Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/ Smad2 signalling pathway. PLoS ONE, 17(11 November). |
| MLA | Li, Zhaoyi,et al."Leonurine inhibits cardiomyocyte pyroptosis to attenuate cardiac fibrosis via the TGF-β/ Smad2 signalling pathway".PLoS ONE 17.11 November(2022). |
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