The feasibility of anaerobic membrane bioreactor (AnMBR) for the treatment of N, N-dimethylformamide (DMF)-containing wastewater was theoretically compared with the conventional activated sludge (CAS) process in this study. The electricity consumption and expenditure, bio-energy production and CO emission were investigated using the operational results of a lab-scale AnMBR operated in a long-term operation. The AnMBR was capable of producing bio-methane from wastewater and generated 3.45 kWh/m of electricity as recovered bio-energy while the CAS just generated 1.17 kWh/m of electricity from the post-treatment of excessive sludge disposal. The large quantity of bio-methane recovered by the AnMBR can also be sold as sustainable bioresource for the use of household natural gas with a theoretical profit gain of 29,821 US$/year, while that of the CAS was unprofitable. The AnMBR was also demonstrated to significantly reduce the carbon emission by obtaining a theoretical negative CO production of −2.34 kg CO/m with the recycle of bio-energy while that for the CAS was 4.50 kg CO/m. The results of this study demonstrate that the AnMBR process has promising potential for the carbon-neutral treatment of high-strength DMF-containing wastewater in the future.