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Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT
Chen,Gefei1; Lu,Zhonglin1; Jiang,Han1; Lin,Ko Han3; Mok,Greta S.P.1,2
2023-03-10
Source PublicationScientific Reports
ISSN2045-2322
Volume13Issue:1Pages:4020
Abstract

Partition model (PM) for Y-90 microsphere radioembolization is limited in providing 3D dosimetrics. Voxel-S-Values (VSV) method has good agreement with Monte Carlo (MC) simulations for 3D absorbed dose conversion. We propose a new VSV method and compare its performance along with PM, MC and other VSV methods for Y-90 RE treatment planning based on Tc-99m MAA SPECT/CT. Twenty Tc-99m-MAA SPECT/CT patient data are retrospectively analyzed. Seven VSV methods are implemented: (1) local energy deposition; (2) liver kernel; (3) liver kernel and lung kernel; (4) liver kernel with density correction (LiKD); (5) liver kernel with center voxel scaling (LiCK); (6) liver kernel and lung kernel with density correction (LiLuKD); (7) proposed liver kernel with center voxel scaling and lung kernel with density correction (LiCKLuKD). Mean absorbed dose and maximum injected activity (MIA) obtained by PM and VSV are evaluated against MC results, and 3D dosimetrics generated by VSV are compared with MC. LiKD, LiCK, LiLuKD and LiCKLuKD have the smallest deviation in normal liver and tumors. LiLuKD and LiCKLuKD have the best performance in lungs. MIAs are similar by all methods. LiCKLuKD could provide MIA consistent with PM, and precise 3D dosimetrics for Y-90 RE treatment planning.

DOI10.1038/s41598-023-30824-4
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000989359600060
Scopus ID2-s2.0-85149951837
Fulltext Access
Citation statistics
Document TypeJournal article
CollectionDEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING
Corresponding AuthorMok,Greta S.P.
Affiliation1.Biomedical Imaging Laboratory (BIG),Department of Electrical and Computer Engineering,Faculty of Science and Technology,University of Macau,Avenida da Universidade,Taipa,SAR,Macao
2.Ministry of Education Frontiers Science Center for Precision Oncology,University of Macau,SAR,Macao
3.Department of Nuclear Medicine,Taipei Veterans General Hospital,Taipei,Taiwan
First Author AffilicationFaculty of Science and Technology
Corresponding Author AffilicationFaculty of Science and Technology;  University of Macau
Recommended Citation
GB/T 7714
Chen,Gefei,Lu,Zhonglin,Jiang,Han,et al. Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT[J]. Scientific Reports, 2023, 13(1), 4020.
APA Chen,Gefei., Lu,Zhonglin., Jiang,Han., Lin,Ko Han., & Mok,Greta S.P. (2023). Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT. Scientific Reports, 13(1), 4020.
MLA Chen,Gefei,et al."Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT".Scientific Reports 13.1(2023):4020.
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