Residential College | false |
Status | 已發表Published |
Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT | |
Chen,Gefei1; Lu,Zhonglin1; Jiang,Han1; Lin,Ko Han3; Mok,Greta S.P.1,2 | |
2023-03-10 | |
Source Publication | Scientific Reports |
ISSN | 2045-2322 |
Volume | 13Issue:1Pages:4020 |
Abstract | Partition model (PM) for Y-90 microsphere radioembolization is limited in providing 3D dosimetrics. Voxel-S-Values (VSV) method has good agreement with Monte Carlo (MC) simulations for 3D absorbed dose conversion. We propose a new VSV method and compare its performance along with PM, MC and other VSV methods for Y-90 RE treatment planning based on Tc-99m MAA SPECT/CT. Twenty Tc-99m-MAA SPECT/CT patient data are retrospectively analyzed. Seven VSV methods are implemented: (1) local energy deposition; (2) liver kernel; (3) liver kernel and lung kernel; (4) liver kernel with density correction (LiKD); (5) liver kernel with center voxel scaling (LiCK); (6) liver kernel and lung kernel with density correction (LiLuKD); (7) proposed liver kernel with center voxel scaling and lung kernel with density correction (LiCKLuKD). Mean absorbed dose and maximum injected activity (MIA) obtained by PM and VSV are evaluated against MC results, and 3D dosimetrics generated by VSV are compared with MC. LiKD, LiCK, LiLuKD and LiCKLuKD have the smallest deviation in normal liver and tumors. LiLuKD and LiCKLuKD have the best performance in lungs. MIAs are similar by all methods. LiCKLuKD could provide MIA consistent with PM, and precise 3D dosimetrics for Y-90 RE treatment planning. |
DOI | 10.1038/s41598-023-30824-4 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Science & Technology - Other Topics |
WOS Subject | Multidisciplinary Sciences |
WOS ID | WOS:000989359600060 |
Scopus ID | 2-s2.0-85149951837 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | DEPARTMENT OF ELECTRICAL AND COMPUTER ENGINEERING |
Corresponding Author | Mok,Greta S.P. |
Affiliation | 1.Biomedical Imaging Laboratory (BIG),Department of Electrical and Computer Engineering,Faculty of Science and Technology,University of Macau,Avenida da Universidade,Taipa,SAR,Macao 2.Ministry of Education Frontiers Science Center for Precision Oncology,University of Macau,SAR,Macao 3.Department of Nuclear Medicine,Taipei Veterans General Hospital,Taipei,Taiwan |
First Author Affilication | Faculty of Science and Technology |
Corresponding Author Affilication | Faculty of Science and Technology; University of Macau |
Recommended Citation GB/T 7714 | Chen,Gefei,Lu,Zhonglin,Jiang,Han,et al. Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT[J]. Scientific Reports, 2023, 13(1), 4020. |
APA | Chen,Gefei., Lu,Zhonglin., Jiang,Han., Lin,Ko Han., & Mok,Greta S.P. (2023). Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT. Scientific Reports, 13(1), 4020. |
MLA | Chen,Gefei,et al."Voxel-S-Value based 3D treatment planning methods for Y-90 microspheres radioembolization based on Tc-99m-macroaggregated albumin SPECT/CT".Scientific Reports 13.1(2023):4020. |
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