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A Portable CMOS-Based Spin Resonance System for High-Resolution Spectroscopy and Imaging
Kruger,Daniel1,2; Zhang,Aoyang1; Aghelnejad,Behdad1,3; Hinton,Henry1; Arnal,Victor Marrugat1,4; Song,Yi Qiao1; Tang,Yiqiao5,6; Lei,Ka Meng7; Anders,Jens2; Ham,Donhee1
2023-07-01
Source PublicationIEEE Journal of Solid-State Circuits
ISSN0018-9200
Volume58Issue:7Pages:1838-1849
Abstract

Nuclear magnetic resonance (NMR) is a paramount analytical tool for chemistry, biology, medicine, and geology, and has a fundamental importance in physics. The recent years have seen a wealth of efforts to miniaturize NMR systems by combining permanent magnets and CMOS radio frequency (RF)-integrated circuits (ICs) to make the benefit of NMR more broadly available beyond dedicated facilities, which have resulted in systems capable of NMR relaxometry first, and later NMR spectroscopy, the two key NMR modalities. Here we report a small NMR system comprising a digitally assisted CMOS RF transceiver IC and a 0.51-T permanent magnet, which not only enhances spectroscopy and relaxometry performance but also includes magnetic resonance imaging (MRI), a powerful variant of relaxometry. The system achieves a spectral resolution of < 0.05 ppm (1.1 Hz), the highest reported in a portable CMOS-based NMR system, and an imaging resolution of 67\times 67 \times 83\,\, \boldsymbol {\mu }\text{m}^{3}.

KeywordBioelectronics Cmos-integrated Circuit (Ic) Magnetic Resonance Imaging (Mri) Nuclear Magnetic Resonance (Nmr) Radio Frequency (Rf) Ic
DOI10.1109/JSSC.2023.3274043
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaEngineering
WOS SubjectEngineering, Electrical & Electronic
WOS IDWOS:001005063600001
Scopus ID2-s2.0-85162864484
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Citation statistics
Document TypeJournal article
CollectionINSTITUTE OF MICROELECTRONICS
Corresponding AuthorHam,Donhee
Affiliation1.Harvard University,Harvard John A. Paulson School of Engineering and Applied Sciences,Cambridge,02138,United States
2.University of Stuttgart,Institute of Smart Sensors,Stuttgart,70569,Germany
3.Oxford Instruments,Abingdon,OX13 5QX,United Kingdom
4.ETH Zurich,Zurich,8092,Switzerland
5.Schlumberger-Doll Research,Cambridge,02139,United States
6.Meta,Menlo Park,94025,United States
7.Faculty of Science and Technology,University of Macau,State Key Laboratory of Analog and Mixed-Signal VLSI,Institute of Microelectronics,Department of ECE,Macau,Macao
Recommended Citation
GB/T 7714
Kruger,Daniel,Zhang,Aoyang,Aghelnejad,Behdad,et al. A Portable CMOS-Based Spin Resonance System for High-Resolution Spectroscopy and Imaging[J]. IEEE Journal of Solid-State Circuits, 2023, 58(7), 1838-1849.
APA Kruger,Daniel., Zhang,Aoyang., Aghelnejad,Behdad., Hinton,Henry., Arnal,Victor Marrugat., Song,Yi Qiao., Tang,Yiqiao., Lei,Ka Meng., Anders,Jens., & Ham,Donhee (2023). A Portable CMOS-Based Spin Resonance System for High-Resolution Spectroscopy and Imaging. IEEE Journal of Solid-State Circuits, 58(7), 1838-1849.
MLA Kruger,Daniel,et al."A Portable CMOS-Based Spin Resonance System for High-Resolution Spectroscopy and Imaging".IEEE Journal of Solid-State Circuits 58.7(2023):1838-1849.
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