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Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats
Wu,Jiazhen1,2; Li,Mengyao1; Huang,Ning1; Guan,Fengkun1; Luo,Huijuan1; Chen,Liping3; Wei,Guilan1; Li,Muxia4; Lin,Zhixiu5; Su,Ziren1,6; Chen,Jiannan1,6; Liu,Yuhong1,6
2023
Source PublicationJournal of Agricultural and Food Chemistry
ISSN0021-8561
Volume71Issue:27Pages:10338-10348
Abstract

Hepatic endothelial function is central to the development of nonalcoholic steatohepatitis (NASH). Curcumin (Cur) is reportedly hepatoprotective, however, it remains unknown whether Cur improves hepatic endothelial function in NASH. Additionally, the poor bioavailability of Cur renders it difficult to elucidate its hepatoprotective effect, hence, its biotransformation should be considered. Herein, we investigated the effects and mechanisms of Cur and its bioconversion on hepatic endothelial function against high-fat diet-induced NASH in rats. The results revealed that Cur improved hepatic lipid accumulation, inflammation, and endothelial dysfunction by inhibiting NF-κB and PI3K/Akt/HIF-1α pathways, however, these effects were weakened via antibiotic addition, which was closely related to reduced tetrahydrocurcumin (THC) produce in the liver and intestinal content. Moreover, THC exerted a better effect than Cur on restoring liver sinusoidal endothelial cells function to attenuate steatosis and injury in L02 cells. Thus, these findings indicate that the effect of Cur on NASH is closely related to hepatic endothelial function improvement with intestinal microbial biotransformation.

KeywordCurcumin Hepatic Endothelial Function Microbial Biotransformation Nonalcoholic Steatohepatitis Tetrahydrocurcumin
DOI10.1021/acs.jafc.3c01067
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:001020637600001
Scopus ID2-s2.0-85164288857
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Document TypeJournal article
CollectionUniversity of Macau
Corresponding AuthorChen,Jiannan; Liu,Yuhong
Affiliation1.School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou,510006,China
2.Shenzhen Key Laboratory of Hospital Chinese Medicine Preparation,Shenzhen Traditional Chinese Medicine Hospital,The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,518033,China
3.Faculty of Health Sciences,University of Macau,Macao,999078,Macao
4.Shenzhen Traditional Chinese Medicine Hospital,Shenzhen,Guangdong,518000,China
5.School of Chinese Medicine,Faculty of Medicine,The Chinese University of Hong Kong,Kowloon,999077,Hong Kong
6.Dongguan Institute of Guangzhou University of Chinese Medicine,Dongguan,523808,China
Recommended Citation
GB/T 7714
Wu,Jiazhen,Li,Mengyao,Huang,Ning,et al. Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats[J]. Journal of Agricultural and Food Chemistry, 2023, 71(27), 10338-10348.
APA Wu,Jiazhen., Li,Mengyao., Huang,Ning., Guan,Fengkun., Luo,Huijuan., Chen,Liping., Wei,Guilan., Li,Muxia., Lin,Zhixiu., Su,Ziren., Chen,Jiannan., & Liu,Yuhong (2023). Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats. Journal of Agricultural and Food Chemistry, 71(27), 10338-10348.
MLA Wu,Jiazhen,et al."Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats".Journal of Agricultural and Food Chemistry 71.27(2023):10338-10348.
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