Residential College | false |
Status | 已發表Published |
Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats | |
Wu,Jiazhen1,2; Li,Mengyao1; Huang,Ning1; Guan,Fengkun1; Luo,Huijuan1; Chen,Liping3; Wei,Guilan1; Li,Muxia4; Lin,Zhixiu5; Su,Ziren1,6; Chen,Jiannan1,6; Liu,Yuhong1,6 | |
2023 | |
Source Publication | Journal of Agricultural and Food Chemistry |
ISSN | 0021-8561 |
Volume | 71Issue:27Pages:10338-10348 |
Abstract | Hepatic endothelial function is central to the development of nonalcoholic steatohepatitis (NASH). Curcumin (Cur) is reportedly hepatoprotective, however, it remains unknown whether Cur improves hepatic endothelial function in NASH. Additionally, the poor bioavailability of Cur renders it difficult to elucidate its hepatoprotective effect, hence, its biotransformation should be considered. Herein, we investigated the effects and mechanisms of Cur and its bioconversion on hepatic endothelial function against high-fat diet-induced NASH in rats. The results revealed that Cur improved hepatic lipid accumulation, inflammation, and endothelial dysfunction by inhibiting NF-κB and PI3K/Akt/HIF-1α pathways, however, these effects were weakened via antibiotic addition, which was closely related to reduced tetrahydrocurcumin (THC) produce in the liver and intestinal content. Moreover, THC exerted a better effect than Cur on restoring liver sinusoidal endothelial cells function to attenuate steatosis and injury in L02 cells. Thus, these findings indicate that the effect of Cur on NASH is closely related to hepatic endothelial function improvement with intestinal microbial biotransformation. |
Keyword | Curcumin Hepatic Endothelial Function Microbial Biotransformation Nonalcoholic Steatohepatitis Tetrahydrocurcumin |
DOI | 10.1021/acs.jafc.3c01067 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Agriculture ; Chemistry ; Food Science & Technology |
WOS Subject | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
WOS ID | WOS:001020637600001 |
Scopus ID | 2-s2.0-85164288857 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | University of Macau |
Corresponding Author | Chen,Jiannan; Liu,Yuhong |
Affiliation | 1.School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou,510006,China 2.Shenzhen Key Laboratory of Hospital Chinese Medicine Preparation,Shenzhen Traditional Chinese Medicine Hospital,The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine,Shenzhen,518033,China 3.Faculty of Health Sciences,University of Macau,Macao,999078,Macao 4.Shenzhen Traditional Chinese Medicine Hospital,Shenzhen,Guangdong,518000,China 5.School of Chinese Medicine,Faculty of Medicine,The Chinese University of Hong Kong,Kowloon,999077,Hong Kong 6.Dongguan Institute of Guangzhou University of Chinese Medicine,Dongguan,523808,China |
Recommended Citation GB/T 7714 | Wu,Jiazhen,Li,Mengyao,Huang,Ning,et al. Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats[J]. Journal of Agricultural and Food Chemistry, 2023, 71(27), 10338-10348. |
APA | Wu,Jiazhen., Li,Mengyao., Huang,Ning., Guan,Fengkun., Luo,Huijuan., Chen,Liping., Wei,Guilan., Li,Muxia., Lin,Zhixiu., Su,Ziren., Chen,Jiannan., & Liu,Yuhong (2023). Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats. Journal of Agricultural and Food Chemistry, 71(27), 10338-10348. |
MLA | Wu,Jiazhen,et al."Curcumin Alleviates High-fat Diet-induced Nonalcoholic Steatohepatitis via Improving Hepatic Endothelial Function with Microbial Biotransformation in Rats".Journal of Agricultural and Food Chemistry 71.27(2023):10338-10348. |
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