Residential College | false |
Status | 已發表Published |
Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents | |
Teng, Hui1; Lin, Qiyang1; Li, Kang1; Yuan, Benyao1; Song, Hongbo1; Peng, Hongquan2; Yi, Lunzhao3; Wei, Ming-Chi4; Yang, Yu-Chiao5; Battino, Maurizio6,7; Cespedes Acuna, Carlos L.8; Chen, Lei1; Xiao, Jianbo1,9 | |
2017-12 | |
Source Publication | FOOD AND CHEMICAL TOXICOLOGY |
ISSN | 0278-6915 |
Volume | 110Pages:418-424 |
Abstract | Raspberry seed is a massive byproduct of raspberry juice and wine but usually discarded. The present study employed a microwave-assisted method for extraction of raspberry seed oil (RSO). The results revealed that omega-6 fatty acids (linoleic acid and gamma-linolenic acid) were the major constituents in RSO. Cellular antioxidant enzyme activity such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were investigated in HepG2 cells treated with RSO. Induction of the synthesis of several antioxidants in H2O2-exposed HepG2 cells was found. RSO increased the enzyme activity of SOD, CAT, and GPx in H2O2-exposed HepG2. Furthermore, RSO inhibited the phosphorylation of upstream mitogen-activated protein kinases (MAPK) such as c-Jun N-terminal kinase (c-JNK)and extracellular signal-regulated kinase (ERK). Taken together, the possible mechanisms to increase antioxidant enzyme activities in HepG2 may through the suppression of ERK and JNK phosphorylation. Raspberry seed oil exhibited good effects on the activities of the intracellular antioxidant enzymes and seems to protect the liver from oxidative stress through the inhibition of MAPKs. (C) 2017 Published by Elsevier Ltd. |
Keyword | Raspberry Seeds Fatty Acids Extraction Antioxidant Enzyme Hepatoprotection |
DOI | 10.1016/j.fct.2017.09.010 |
URL | View the original |
Indexed By | SCIE |
Language | 英語English |
WOS Research Area | Food Science & Technology ; Toxicology |
WOS Subject | Food Science & Technology ; Toxicology |
WOS ID | WOS:000418211700040 |
Publisher | PERGAMON-ELSEVIER SCIENCE LTD |
The Source to Article | WOS |
Scopus ID | 2-s2.0-85032899578 |
Fulltext Access | |
Citation statistics | |
Document Type | Journal article |
Collection | University of Macau |
Affiliation | 1.College of Food Science, Fujian Agriculture and Forestry University, 15 Shangxiadian Road, 350002 Fuzhou, China 2.Kiang Wu Hospital, Macau, China 3.Yunnan Food Safety Research Institute, Kunming University of Science and Technology, Kunming, China 4.Department of Applied Geoinformatics, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan 5.Department and Graduate Institute of Pharmacology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan 6.Center for Nutrition & Health, Universidad Europea del Atlantico, Santander, Spain 7.Department of Clinical Sciences, University Nutrition & Health, Universidad Europea, Spain 8.Plant Biochemistry and Phytochemical Ecology Lab, Basic Sciences Department University of Bio Bio, Andres Bello Av. s/n, Casilla 447, Chillan, Chile 9.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Taipa, Macao |
Recommended Citation GB/T 7714 | Teng, Hui,Lin, Qiyang,Li, Kang,et al. Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents[J]. FOOD AND CHEMICAL TOXICOLOGY, 2017, 110, 418-424. |
APA | Teng, Hui., Lin, Qiyang., Li, Kang., Yuan, Benyao., Song, Hongbo., Peng, Hongquan., Yi, Lunzhao., Wei, Ming-Chi., Yang, Yu-Chiao., Battino, Maurizio., Cespedes Acuna, Carlos L.., Chen, Lei., & Xiao, Jianbo (2017). Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents. FOOD AND CHEMICAL TOXICOLOGY, 110, 418-424. |
MLA | Teng, Hui,et al."Hepatoprotective effects of raspberry (Rubus coreanus Miq.) seed oil and its major constituents".FOOD AND CHEMICAL TOXICOLOGY 110(2017):418-424. |
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