| Status | 已發表Published |
| Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy | |
Xie, L.; Li, J.; Wang, G. ; Sang, W.; Xu, M.; Li, W.; Yan, J.; Li, B.; Zhang, Z.; Zhao, Q.; Yuan, Z.; Fan, Q.; Dai, Y. 
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| 2022-01-05 | |
| Source Publication | Journal of the American Chemical Society
 |
| ISSN | 0002-7863 |
| Pages | 787-797 |
| Abstract | Tumor-derived exosome can suppress dendritic cells (DCs) and T cells functions. Excessive secretion of exosomal programmed death-ligand 1 (PD-L1) results in therapeutic resistance to PD-1/PD-L1 immunotherapy and clinical failure. Restored T cells by antiexosomal PD-L1 tactic can intensify ferroptosis of tumor cells and vice versa. Diminishing exosomal suppression and establishing a nexus of antiexosomal PD-L1 and ferroptosis may rescue the discouraging antitumor immunity. Here, we engineered phototheranostic metal-phenolic networks (PFG MPNs) by an assembly of semiconductor polymers encapsulating ferroptosis inducer (Fe3+) and exosome inhibitor (GW4869). The PFG MPNs elicited superior near-infrared II fluorescence/photoacoustic imaging tracking performance for a precise photothermal therapy (PTT). PTT-augmented immunogenic cell death relieved exosomal silencing on DC maturation. GW4869 mediated PD-L1 based exosomal inhibition revitalized T cells and enhanced the ferroptosis. This novel synergy of PTT with antiexosomal PD-L1 enhanced ferroptosis evoked potent antitumor immunity in B16F10 tumors and immunological memory against metastatic tumors in lymph nodes. |
| Keyword | Metal-Phenolic Networks Ferroptosis Immunotherapy |
| URL | View the original |
| Language | 英語English |
| The Source to Article | PB_Publication |
| PUB ID | 62876 |
| Document Type | Journal article |
| Collection | DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION |
| Corresponding Author | Dai, Y. |
| Recommended Citation GB/T 7714 | Xie, L.,Li, J.,Wang, G.,et al. Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy[J]. Journal of the American Chemical Society, 2022, 787-797. |
| APA | Xie, L.., Li, J.., Wang, G.., Sang, W.., Xu, M.., Li, W.., Yan, J.., Li, B.., Zhang, Z.., Zhao, Q.., Yuan, Z.., Fan, Q.., & Dai, Y. (2022). Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy. Journal of the American Chemical Society, 787-797. |
| MLA | Xie, L.,et al."Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy".Journal of the American Chemical Society (2022):787-797. |
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