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Subtype-specific cardiomyocytes for precision medicine: Where are we now?
Zhao, Ming Tao1,2; Shao, Ning Yi3; Garg, Vidu1,2,4
Source PublicationStem Cells
ISSN1066-5099
2020-07-01
Abstract

Patient-derived pluripotent stem cells (PSCs) have greatly transformed the current understanding of human heart development and cardiovascular disease. Cardiomyocytes derived from personalized PSCs are powerful tools for modeling heart disease and performing patient-based cardiac toxicity testing. However, these PSC-derived cardiomyocytes (PSC-CMs) are a mixed population of atrial-, ventricular-, and pacemaker-like cells in the dish, hindering the future of precision cardiovascular medicine. Recent insights gleaned from the developing heart have paved new avenues to refine subtype-specific cardiomyocytes from patients with known pathogenic genetic variants and clinical phenotypes. Here, we discuss the recent progress on generating subtype-specific (atrial, ventricular, and nodal) cardiomyocytes from the perspective of embryonic heart development and how human pluripotent stem cells will expand our current knowledge on molecular mechanisms of cardiovascular disease and the future of precision medicine.

KeywordAtrial Cardiomyocytes Human Pluripotent Stem Cells Nodal Cardiomyocytes Subtype-specific Cardiomyocytes Ventricular Cardiomyocytes
Language英語English
DOI10.1002/stem.3178
URLView the original
Volume38
Issue7
Pages822-833
Scopus ID2-s2.0-85084159459
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Document TypeReview article
CollectionFaculty of Health Sciences
Affiliation1.Center for Cardiovascular Research, The Abigail Wexner Research Institute and The Heart Center, Nationwide Children's Hospital, Columbus, United States
2.Department of Pediatrics, The Ohio State University College of Medicine, Columbus, United States
3.Faculty of Health Sciences, University of Macau, Macau, China
4.Department of Molecular Genetics, The Ohio State University College of Medicine, Columbus, United States
Recommended Citation
GB/T 7714
Zhao, Ming Tao,Shao, Ning Yi,Garg, Vidu. Subtype-specific cardiomyocytes for precision medicine: Where are we now?[J]. Stem Cells, 2020, 38(7), 822-833.
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