Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy

UM > Faculty of Health Sciences > DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION

Status	已發表Published
	Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy
	Xie, L.; Wang, G.; Sang, W.; Li, J.; Zhang, Z.; Li, W.; Yan, J.; Zhao, Q.; Dai, Y.
	2021-02-01
Source Publication	Biomaterials
ISSN	0142-9612
Pages	120638-120638
Abstract	A critical challenge remains in PD-1 checkpoint blockade immunotherapy is few tumor specific T cells infiltration in hypoxic tumor microenvironment (TME). Improving immunogenic cell death (ICD) associated immunogenicity can make tumor sensitive to PD-1 checkpoint blockade immunotherapy. Herein, a phenolic ICD inducer was engineered by self-assembly of the superior ICD inducer (doxorubicin, DOX), phenolic manganese dioxide nanoreactor, ferric iron and PEG-polyphenols (MDP NPs) via metal phenolic coordination. These oxygen self-supporting MDP NPs strengthen DOX based ROS-dependent cell death and their metal mediated chemodynamic effect accelerate ICD induction. Together with concomitant ICD triggered by DOX, MDP NPs successively lead to tumor-associated antigen boosting, DCs maturation and ultimately enhance tumor-specific T cells infiltration. Furthermore, MDP NPs efficiently modulated hypoxic TME for effective macrophages recruitment. This promising ICD-augment strategy efficiently improve tumor response to PD-1 checkpoint blockade immunotherapy, resulting in a significant antitumor immune response in primary tumor and a strong abscopal effect to distant tumor. Our simple and versatile phenolic inducer expands the application of chemodrugs based ICD enhancing PD-1 checkpoint blockade immunotherapy.
Keyword	Immunogenic cell death Metal phenolic coordination PD-1 immune checkpoint blockade immunotherapy Phenolic nanoplatform.
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	56434
Document Type	Journal article
Collection	DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION
Corresponding Author	Dai, Y.
Recommended Citation GB/T 7714	Xie, L.,Wang, G.,Sang, W.,et al. Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy[J]. Biomaterials, 2021, 120638-120638.
APA	Xie, L.., Wang, G.., Sang, W.., Li, J.., Zhang, Z.., Li, W.., Yan, J.., Zhao, Q.., & Dai, Y. (2021). Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy. Biomaterials, 120638-120638.
MLA	Xie, L.,et al."Phenolic immunogenic cell death nanoinducer for sensitizing tumor to PD-1 checkpoint blockade immunotherapy".Biomaterials (2021):120638-120638.

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