Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

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	Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity
	Han, BN; Liang, TT; Keen, LJ; Fan, TT; Zhang, XD; Xu, L; Zhao, Q.; Wang, SP; Lin, HW
	2018
Source Publication	Organic Letters
ISSN	1523-7060
Pages	578-581
Abstract	The isolation and structure elucidation of two cyanobacterial debromoaplysiatoxin (DAT) analogues, neo-debromoaplysiatoxin A (1) and neo-debromoaplysiatoxin B (2), were reported and found to possess 6/10/6 and 6/6/6 fused-ring systems, respectively, which are rarely seen among aplysiatoxins. Both compounds exhibited potent blocking activity against Kv1.5 with IC50 values of 6.94 ± 0.26 and 0.30 ± 0.05 μM, respectively. These findings suggest the potential of aplysiatoxin analogues in modulating ionic channels and also provide links between the DAT target, protein kinase C, and cell regulation.
Keyword	Neo-debromoaplysiatoxin K+ Channel
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	37617
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Han, BN; Lin, HW
Recommended Citation GB/T 7714	Han, BN,Liang, TT,Keen, LJ,et al. Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity[J]. Organic Letters, 2018, 578-581.
APA	Han, BN., Liang, TT., Keen, LJ., Fan, TT., Zhang, XD., Xu, L., Zhao, Q.., Wang, SP., & Lin, HW (2018). Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity. Organic Letters, 578-581.
MLA	Han, BN,et al."Two Marine Cyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, with K+ Channel Inhibition Activity".Organic Letters (2018):578-581.

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