Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome
	HAO, DP; LI, JJ; WANG, JL; ZHAO, ZQ; Wang, L.; Di, L.
	2019-09-01
Source Publication	Theranostics
ISSN	1838-7640
Pages	3952-3965
Abstract	Deficiency in homologous recombination repair (HRR) is frequently associated with hormone-responsive cancers, especially the epithelial ovarian cancer (EOC) which shows defects of HRR in up to half of cases. However, whether there are molecular connections between estrogen signaling and HRR deficiency in EOC remains unknown. Methods: We analyzed the estrogen receptor α (ERα) binding profile in EOC cell lines and investigated its association with genome instability, HRR deficiency and sensitivity to chemotherapy using extensive public datasets and in vitro/in vivo experiments. Results: We found an inverse correlation between estrogen signaling and HRR activity in EOC, and the genome-wide collaboration between ERα and the co-repressor CtBP. Though the non-classical AP-1-mediated ERα signaling, their targets were highly enriched by HRR genes. We found that depleting ERα in EOC cells up-regulates HRR activity and HRR gene expression. Consequently, estrogen signaling enhances the sensitivity of ovarian cancer cells to chemotherapy agents in vitro and in vivo. Large-scale analyses further indicate that estrogen replacement and ESR1 expression are associated with chemo-sensitivity and the favorable survival of EOC patients. Conclusion: These findings characterize a novel role of ERα in mediating the molecular connection between hormone and HRR in EOC and encourage hormone replacement therapy for EOC patients.
Keyword	Ovarian cancer Estrogen signaling Deficiency of homologous-recombination Chemotherapy Hormone replacement
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	59584
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Wang, L.; Di, L.
Recommended Citation GB/T 7714	HAO, DP,LI, JJ,WANG, JL,et al. Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome[J]. Theranostics, 2019, 3952-3965.
APA	HAO, DP., LI, JJ., WANG, JL., ZHAO, ZQ., Wang, L.., & Di, L. (2019). Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome. Theranostics, 3952-3965.
MLA	HAO, DP,et al."Non-classical estrogen signaling in ovarian cancer improves chemo-sensitivity and patients outcome".Theranostics (2019):3952-3965.

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh