Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

Status	已發表Published
	Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy
	Li, J; Hao, H; Wang, L.; Wang, H; Wang, Y; Zhao, Z; Li, P; Chuxia, D.; Di, L.
	2017-06-22
Source Publication	Scientific Reports
ISSN	2045-2322
Pages	1-12
Abstract	Epigenetic therapy is a novel tumor therapeutic method and refers to the targeting of the aberrant epigenetic modifications presumably at cancer-related genes by chemicals which are epigenetic targeting drugs (ETDs). Not like in treating hematopoietic cancer, the clinical trials investigating the potential use of ETDs in the solid tumor is not encouraging. Instead, the curative effects of ETD delivered together with DNA targeting chemo drugs (DTDs) are quite promising according to our meta-analysis. To investigate the synergistic mechanism of ETD and DTD drug combination, the therapeutic effect was studied using both cell lines and mouse engrafted tumors. Mechanically we show that HDAC inhibitors and DNMT inhibitors are capable of increasing the chromatin accessibility to cisplatin (CP) and doxorubicin (Dox) through chromatin decompaction globally. Consequently, the combination of ETD and DTD enhances the DTD induced DNA damage and cell death. Engrafted tumors in SCID mice also show increased sensitivity to irradiation (IR) or CP when the tumors were pretreated by ETDs. Given the limited therapeutic effect of ETD alone, these results strongly suggest that the combination of DTD, including irradiation, and ETD treatment is a very promising choice in clinical solid tumor therapy.
Keyword	epigenetic targeting drugs tumor therapeutic method DNA targeting chemo drugs
URL	View the original
Language	英語English
The Source to Article	PB_Publication
PUB ID	31311
Document Type	Journal article
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	Di, L.
Recommended Citation GB/T 7714	Li, J,Hao, H,Wang, L.,et al. Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy[J]. Scientific Reports, 2017, 1-12.
APA	Li, J., Hao, H., Wang, L.., Wang, H., Wang, Y., Zhao, Z., Li, P., Chuxia, D.., & Di, L. (2017). Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy. Scientific Reports, 1-12.
MLA	Li, J,et al."Epigenetic targeting drugs potentiate chemotherapeutic effects in solid tumor therapy".Scientific Reports (2017):1-12.

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