This article examines the politicization of the World Health Organization (WHO) over the course of the coronavirus pandemic (January–December 2020), a paradigmatic case of politicization of global governance institutions. During the pandemic, the WHO was subjected to considerable scrutiny and contestation. This research focuses on politicization at the level of behavior and discourse. Conceptually, it leverages the analytic purchase of politicization and framing. Empirically, it is based on a corpus comprising 505 texts gathered from key actors involved. The analysis not only lays bare the varying demands and arguments vis-à-vis the WHO, but foregrounds the broad consensus among the actors examined (barring the Donald Trump administration) on the imperative to support the organization. Additionally, seven distinct frames on the WHO are identified: Puppet, Handcuffed, Scapegoat, Irreplaceable, Botched, Comme il faut, and Battleground. Together, they offer a holistic overview of the diverse perspectives on the WHO and its pandemic response.