Secularization, expansion of higher education, and urbanization have led to disenchantment with politics and the erosion of political trust in many societies. Religion may continue to be salient, however, how these forces interact with enduring religious influences to shape political trust is unclear. This paper examines the issue using Asian Barometer Survey (2001–2016) data with hierarchical age–period–cohort (HAPC) models. Our results show supportive evidence for the following findings: in East and Southeast Asia, urbanization is associated with less political trust for most religions except Islam; education is associated with less political trust; education's effect is the most salient for the atheists and Buddhists, but it disappears among the Muslims. The findings suggest the power of modernization and secularization significantly differs across cultures and religions. We should not simply perceive religion as a universally conservative force; instead, we need to understand religions through an integrated macro-micro perspective by situating it in the social contexts.