US patent No. US 9,259,396 B2: Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid

UM > Faculty of Health Sciences

Residential College	false
Patent Number	US 9,259,396 B2
Status	已授權 Granted
	US patent No. US 9,259,396 B2: Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid
Year Issued	2016
	2016-02-16
Application Number	13/733,901
Application Date	2013
Rights Holder	Nano and Advanced Materials Institute Limited, Hong Kong (HK)
	Luo, Qian; Xu, Jinjie
Country	USA
Subtype	发明专利 Invention
Abstract	The present invention relates to a method of preparing a solid form of soy isoflavone (e.g. genistein). In particular, the present invention relates to a method of preparing a solid form of soy isoflavone by precipitation with compressed antisolvent using a supercritical fluid to produce nano-sized particles of soy isoflavone with an improved dissolution rate and bioavai1ability. An oral composition or aerosolized formulation comprising the nanoparticles of the soy isoflavone pre pared by the method of the present invention is also disclosed herein. The dissolution rate and bioavailability of the nano-particles of the soy isoflavone prepared by the method of the present invention have a 2-fold increase and a 2.6-fold increase respectively as compared to those of the raw soy isoflavone.
Keyword	Soy Isoflavones, Nanotechnology, Antisolvent, Water Solubility, Bioavailability
Document Type	Patent
Collection	Faculty of Health Sciences
Corresponding Author	Luo, Qian
Affiliation	Hong Kong University of Science and Technology
Recommended Citation GB/T 7714	Luo, Qian,Xu, Jinjie. US patent No. US 9,259,396 B2: Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid. US 9,259,396 B2[P]. 2016-02-16.
APA	Luo, Qian., & Xu, Jinjie (2013). US patent No. US 9,259,396 B2: Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid.

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