| Residential College | false |
| Status | 已發表Published |
| Engineering metal-phenolic networks for enhancing cancer therapy by tumor microenvironment modulation | |
Xie, Lisi1; Li, Jie2; Wang, Leyu3; Dai, Yunlu4,5
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| 2023-05-01 | |
| Source Publication | Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology
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| ISSN | 1939-5116 |
| Volume | 15Issue:3 |
| Abstract | The complicated tumor microenvironment (TME) is featured by low pH values, high redox status, and hypoxia, which greatly supports the genesis, development, and metastasis of tumors, leading to drug resistance and clinical failure. Moreover, a lot of immunosuppressive cells infiltrate in such TME, resulting in depressing immunotherapy. Therefore, the development of TME-responsive nanoplatforms has shown great significance in enhancing cancer therapeutics. Metal-phenolic networks (MPNs)-based nanosystems, which self-assemble via coordination of phenolic materials and metal ions, have emerged as excellent TME theranostic nanoplatforms. MPNs have unique properties including fast preparation, tunable morphologies, pH response, and biocompatibility. Besides, functionalization and surface modification can endow MPNs with specific functions for application requirements. Here, the representative engineering strategies of various polyphenols are first introduced, followed by the introduction of the engineering mechanisms of polyphenolic nanosystems, fabrication, and distinct properties of MPNs. Then, their advances in TME modulation are highlighted, such as antiangiogenesis, hypoxia relief, combination therapy sensitization, and immunosuppressive TME reversion. Finally, we will discuss the challenges and future perspectives of MPNs-based nanosystems for enhancing cancer therapy. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease. |
| Keyword | cancer therapy metal-phenolic networks nanomedicine tumor microenvironment modulation |
| DOI | 10.1002/wnan.1864 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85141361657 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF PUBLIC HEALTH AND MEDICINAL ADMINISTRATION |
| Affiliation | 1.Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA Medicine, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China 2.Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing, China 3.Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, China 4.Cancer Center and Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Macao 5.MOE Frontiers Science Center for Precision Oncology, University of Macau, Macao |
| Recommended Citation GB/T 7714 | Xie, Lisi,Li, Jie,Wang, Leyu,et al. Engineering metal-phenolic networks for enhancing cancer therapy by tumor microenvironment modulation[J]. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2023, 15(3). |
| APA | Xie, Lisi., Li, Jie., Wang, Leyu., & Dai, Yunlu (2023). Engineering metal-phenolic networks for enhancing cancer therapy by tumor microenvironment modulation. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 15(3). |
| MLA | Xie, Lisi,et al."Engineering metal-phenolic networks for enhancing cancer therapy by tumor microenvironment modulation".Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 15.3(2023). |
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