Multi-functional chitosan-based nanoparticles for drug delivery: Recent advanced insight into cancer therapy

doi:10.1016/j.carbpol.2023.120972

Residential College	false
Status	已發表Published
	Multi-functional chitosan-based nanoparticles for drug delivery: Recent advanced insight into cancer therapy
	Tian, Bingren 1,3; Hua, Shiyao 2; Liu, Jiayue 2
	2023-09-01
Source Publication	Carbohydrate Polymers
ISSN	0144-8617
Volume	315
Abstract	Cancer therapy continues to be a major global concern, with conventional treatments suffering from low efficacy, untargeted drug delivery, and severe side effects. Recent research in nanomedicine suggests that nanoparticles' unique physicochemical properties can be leveraged to surmount the limitations of conventional cancer treatment. Chitosan-based nanoparticles have gained significant attention due to their high drug-carrying capacity, non-toxicity, biocompatibility, and long circulation time. Chitosan is utilized in cancer therapies as a carrier to accurately deliver active ingredients to tumor sites. This review focuses on clinical studies and current market offerings of anticancer drugs. The unique nature of tumor microenvironments presents new opportunities for the development of smart drug delivery systems, and this review explores the design and preparation of chitosan-based smart nanoparticles. Further, we discuss the therapeutic efficacies of these nanoparticles based on various in vitro and in vivo findings. Finally, we present a forward-looking perspective on the challenges and prospects of chitosan-based nanoparticles in cancer therapy, intending to provide fresh ideas for advancing cancer treatment strategies.
Keyword	Cancer therapy Chitosan nanoparticle Intelligent carrier Preparation Therapeutic effect
DOI	10.1016/j.carbpol.2023.120972
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85158837676
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 3.Key Laboratory of Ningxia Stem Cell and Regenerative Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China
Recommended Citation GB/T 7714	Tian, Bingren,Hua, Shiyao,Liu, Jiayue. Multi-functional chitosan-based nanoparticles for drug delivery: Recent advanced insight into cancer therapy[J]. Carbohydrate Polymers, 2023, 315.
APA	Tian, Bingren., Hua, Shiyao., & Liu, Jiayue (2023). Multi-functional chitosan-based nanoparticles for drug delivery: Recent advanced insight into cancer therapy. Carbohydrate Polymers, 315.
MLA	Tian, Bingren,et al."Multi-functional chitosan-based nanoparticles for drug delivery: Recent advanced insight into cancer therapy".Carbohydrate Polymers 315(2023).

Files in This Item:
There are no files associated with this item.

If you have any objections to this item, please fill out the form below and the administrator will contact you as soon as possible.
Content:
Email：	*
Affiliation No.
Verification Code:	Refresh

Any comments and suggestions are welcomed.
Title:	*
Content:
Email：	*
Verification Code:	Refresh