| Residential College | false |
| Status | 已發表Published |
| Marine Cyanobacterial Peptides in Neuroblastoma: Search for Better Therapeutic Options | |
Ahmed, Salman1; Alam, Waqas2; Aschner, Michael3; Filosa, Rosanna4; Cheang, Wai San5 ; Jeandet, Philippe6; Saso, Luciano7; Khan, Haroon2
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| 2023-05-01 | |
| Source Publication | Cancers
 |
| Volume | 15Issue:9 |
| Abstract | Neuroblastoma is the most prevalent extracranial solid tumor in pediatric patients, originating from sympathetic nervous system cells. Metastasis can be observed in approximately 70% of individuals after diagnosis, and the prognosis is poor. The current care methods used, which include surgical removal as well as radio and chemotherapy, are largely unsuccessful, with high mortality and relapse rates. Therefore, attempts have been made to incorporate natural compounds as new alternative treatments. Marine cyanobacteria are a key source of physiologically active metabolites, which have recently received attention owing to their anticancer potential. This review addresses cyanobacterial peptides’ anticancer efficacy against neuroblastoma. Numerous prospective studies have been carried out with marine peptides for pharmaceutical development including in research for anticancer potential. Marine peptides possess several advantages over proteins or antibodies, including small size, simple manufacturing, cell membrane crossing capabilities, minimal drug–drug interactions, minimal changes in blood–brain barrier (BBB) integrity, selective targeting, chemical and biological diversities, and effects on liver and kidney functions. We discussed the significance of cyanobacterial peptides in generating cytotoxic effects and their potential to prevent cancer cell proliferation via apoptosis, the activation of caspases, cell cycle arrest, sodium channel blocking, autophagy, and anti-metastasis behavior. |
| Keyword | antimetastatic apoptosis autophagy cell cycle arrest marine cyanopeptides |
| DOI | 10.3390/cancers15092515 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85159194456 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Affiliation | 1.Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, 75270, Pakistan 2.Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan 3.Department of Molecular Pharmacology, Albert Einstein College of Medicine Forchheimer, Bronx, 209 1300 Morris Park Avenue, 10461, United States 4.Department of Science and Technology, University of Sannio, Benevento, 82100, Italy 5.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao 6.Faculty of Sciences, RIBP-USC INRAe 1488, University of Reims, Reims, 51100, France 7.Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University, Rome, 00185, Italy |
| Recommended Citation GB/T 7714 | Ahmed, Salman,Alam, Waqas,Aschner, Michael,et al. Marine Cyanobacterial Peptides in Neuroblastoma: Search for Better Therapeutic Options[J]. Cancers, 2023, 15(9). |
| APA | Ahmed, Salman., Alam, Waqas., Aschner, Michael., Filosa, Rosanna., Cheang, Wai San., Jeandet, Philippe., Saso, Luciano., & Khan, Haroon (2023). Marine Cyanobacterial Peptides in Neuroblastoma: Search for Better Therapeutic Options. Cancers, 15(9). |
| MLA | Ahmed, Salman,et al."Marine Cyanobacterial Peptides in Neuroblastoma: Search for Better Therapeutic Options".Cancers 15.9(2023). |
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