| Residential College | false |
| Status | 已發表Published |
| Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms | |
| Liu, Qiao1; Lu, Jin Jian1,2; Hong, Hui Jie1; Yang, Qi1; Wang, Yitao1; Chen, Xiao Jia1,2,3 | |
| 2023-05-01 | |
| Source Publication | Phytomedicine
 |
| ISSN | 0944-7113 |
| Volume | 113 |
| Abstract | Background: Ophiopogon japonicus (Thunb.) Ker Gawl., a well-known Chinese herb, has been used in traditional Chinese medicine for thousands of years. Extensive in vitro and in vivo studies have shown that O. japonicus and its active compounds exhibit potential anticancer effects in a variety of cancer cells in vitro and suppress tumor growth and metastasis without causing serious toxicity in vivo. Purpose: This review aims to systemically summarize and discuss the anticancer effects and the underlying mechanisms of O. japonicus extracts and its active compounds. Methods: The review is prepared following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Various scientific databases including Web of Science, PubMed, Scopus, and Chinese National Knowledge Infrastructure were searched using the keywords: Ophiopogon japonicus, tumor, cancer, carcinoma, content, pharmacokinetics, and toxicity. Results: O. japonicus extracts and the active compounds, such as ruscogenin-1-O-[β-D-glucopyranosyl(1→2)][β-D-xylopyranosyl(1→3)]-β-D-fucopyranoside (DT-13), ophiopogonin B, and ophiopogonin D, exert potential anticancer effects, including the induction of cell cycle arrest, activation of apoptosis and autophagy, and inhibition of metastasis and angiogenesis. In addition, the mechanisms underlying these effects, as well as the pharmacokinetics, toxicity and clinical utility of O. japonicus extracts and active compounds are discussed. Furthermore, this review highlights the research and application prospects of these compounds in immunotherapy and combination chemotherapy. Conclusions: The traditional herb O. japonicus and its phytochemicals could be safe and reliable anticancer drug candidates, alone or in combination with chemotherapeutic drugs. We hope that this review, which highlights the anticancer properties of O. japonicus, will contribute to drug optimization, therapeutic development, and future studies on cancer therapies based on this medicinal plant. |
| Keyword | Anticancer Apoptosis Cell cycle arrest Mechanism Metastasis Ophiopogon japonicus |
| DOI | 10.1016/j.phymed.2023.154718 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85148771148 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Institute of Chinese Medical Sciences, and State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR, 999078, China 2.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao SAR, 999078, China 3.Zhuhai UM Science & Technology Research Institute, Zhuhai, 519031, China |
| First Author Affilication | Institute of Chinese Medical Sciences |
| Recommended Citation GB/T 7714 | Liu, Qiao,Lu, Jin Jian,Hong, Hui Jie,et al. Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms[J]. Phytomedicine, 2023, 113. |
| APA | Liu, Qiao., Lu, Jin Jian., Hong, Hui Jie., Yang, Qi., Wang, Yitao., & Chen, Xiao Jia (2023). Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms. Phytomedicine, 113. |
| MLA | Liu, Qiao,et al."Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms".Phytomedicine 113(2023). |
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