| Residential College | false |
| Status | 已發表Published |
| The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone | |
Shao, Zeyang1; Wang, Heng1; Ren, Haiyan1; Sun, Yinxiang2; Chen, Xiuping1,3,4,5
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| 2023-08-01 | |
| Source Publication | Molecules
 |
| Volume | 28Issue:15 |
| Abstract | Napabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, and suppresses metastasis and relapse. Such anticancer activities of napabucasin mainly rely on the inhibition of cancer stemness by targeting signal transducer and activator of transcription 3 (STAT3) and its related gene inhibition. However, several novel molecular targets for napabucasin, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and thioredoxin reductase 1 (TrxR1), have been reported. Napabucasin represents a promising anticancer lead for multiple cancers. In this mini review, the anticancer potential and the molecular mechanism of napabucasin will be briefly highlighted. |
| Keyword | cancer napabucasin NQO1 STAT3 |
| DOI | 10.3390/molecules28155678 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85167768712 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Affiliation | 1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao 2.Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, 519000, China 3.Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macao 4.MoE Frontiers Science Center for Precision Oncology, University of Macau, Macao 5.GMU-GIBH Joint School of Life Sciences, The Guangdong-Hong Kong-Macau Joint Laboratory for Cell Fate Regulation and Disease, Guangzhou Medical University, Guangzhou, 511436, China |
| First Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Shao, Zeyang,Wang, Heng,Ren, Haiyan,et al. The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone[J]. Molecules, 2023, 28(15). |
| APA | Shao, Zeyang., Wang, Heng., Ren, Haiyan., Sun, Yinxiang., & Chen, Xiuping (2023). The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone. Molecules, 28(15). |
| MLA | Shao, Zeyang,et al."The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone".Molecules 28.15(2023). |
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