Application of CRISPR/Cas9-based genome editing in ecotoxicology

doi:10.1016/j.envpol.2023.122458

Residential College	false
Status	已發表Published
	Application of CRISPR/Cas9-based genome editing in ecotoxicology
	Zhao, Fang 1,2,3; Ding, Xiaofan 4; Liu, Zimeng 1; Yan, Xiao 2; Chen, Yanzhen 4; Jiang, Yaxin 1; Chen, Shunjie 1; Wang, Yuanfang 1; Kang, Tingting 1; Xie, Chun 3; He, Mian 1; Zheng, Jing 2
	2023-11-01
Source Publication	Environmental Pollution
ISSN	0269-7491
Volume	336
Abstract	Chemicals are widely used and released into the environment, and their degradation, accumulation, migration, and transformation processes in the environment can pose a threat to the ecosystem. The advancement in analytical methods with high-throughput screening of biomolecules has revolutionized the way toxicologists used to explore the effects of chemicals on organisms. CRISPR/Cas is a newly developed tool, widely used in the exploration of basic science and biologically engineered products given its high efficiency and low cost. For example, it can edit target genes efficiently, and save loss of the crop yield caused by environmental pollution as well as gain a better understanding of the toxicity mechanisms from various chemicals. This review briefly introduces the development history of CRISPR/Cas and summarizes the current application of CRISPR/Cas in ecotoxicology, including its application on improving crop yield and drug resistance towards agricultural pollution, antibiotic pollution and other threats. The benefits by applying the CRISPR/Cas9 system in conventional toxicity mechanism studies are fully demonstrated here together with its foreseeable expansions in other area of ecotoxicology. Finally, the prospects and disadvantages of CRISPR/Cas system in the field of ecotoxicology are also discussed.
Keyword	Agricultural pollution Antibiotic resistance Chemical toxicity CRISPR/Cas Ecotoxicology
DOI	10.1016/j.envpol.2023.122458
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85169020470
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China 2.State Environmental Protection Key laboratory of Environmental Pollution Health Risk Assessment, South China Institute of Environmental Sciences. Ministry of Environmental Protection, Guangzhou, China 3.School of Public Health, Guizhou Medical University, Guizhou, China 4.Faculty of Health Sciences, University of Macau, Taipa, Macao SAR, China
Recommended Citation GB/T 7714	Zhao, Fang,Ding, Xiaofan,Liu, Zimeng,et al. Application of CRISPR/Cas9-based genome editing in ecotoxicology[J]. Environmental Pollution, 2023, 336.
APA	Zhao, Fang., Ding, Xiaofan., Liu, Zimeng., Yan, Xiao., Chen, Yanzhen., Jiang, Yaxin., Chen, Shunjie., Wang, Yuanfang., Kang, Tingting., Xie, Chun., He, Mian., & Zheng, Jing (2023). Application of CRISPR/Cas9-based genome editing in ecotoxicology. Environmental Pollution, 336.
MLA	Zhao, Fang,et al."Application of CRISPR/Cas9-based genome editing in ecotoxicology".Environmental Pollution 336(2023).

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