| Residential College | false |
| Patent Number | UMPT0687-2023 |
| Status | 申請中 Pending |
| 一种高亲和性全人源抗Her2单克隆抗体及其制备方法与应用 | |
| Year Issued | 2024 |
| 2024-02 | |
| Application Number | NA |
| Application Date | 2024-02 |
| Rights Holder | University of Macau |
ZHAO QI 
| |
| Country | China |
| Subtype | 发明专利 Invention |
| Abstract | 本发明属于生物医药技术领域，公开了一种高亲和性全人源抗Her2单克隆抗体及其制备方法与应用，具体公开了一种抗Her2单克隆抗体。本发明提供Ab5和Ab8抗体是从人源天然噬菌体抗体文库中鉴定出的，Ab5m是通过在重链可变区的互补决定区（CDR）引入氨基酸突变而亲和力成熟的Ab5抗体。上述Her2抗体拥有与已经公布的同类抗体不同的序列及不同抗原表位识别区，相对于商业化抗体赫赛汀，这些抗体具有更好的抗原结合能力和更高的抗肿瘤功效。此外，Ab5m显示出更高的Her2抗原亲和力值和更强的抗肿瘤能力。 |
| Document Type | Patent |
| Collection | Faculty of Health Sciences |
| Corresponding Author | ZHAO QI |
| Affiliation | Faculty of Health Science, University of Macau |
| Recommended Citation GB/T 7714 | ZHAO QI. 一种高亲和性全人源抗Her2单克隆抗体及其制备方法与应用. UMPT0687-2023[P]. 2024-02-01. |
| APA | ZHAO QI.(2024-02). 一种高亲和性全人源抗Her2单克隆抗体及其制备方法与应用. |
| Files in This Item: | Download All | |||||
| File Name/Size | Publications | Version | Access | License | ||
| 一种高亲和性全人源抗Her2单克隆抗体及（9734KB） | 专利 | 开放获取 | CC BY-NC-SA | View Download | ||
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