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From mundane to classic: Sinomenine as a multi-therapeutic agent
Li, Dan1; Zhong, Zhangfeng2; Ko, Chung Nga3; Tian, Tiantian4; Yang, Chao5
2023-10
Source PublicationBritish Journal of Pharmacology
ISSN0007-1188
Abstract

Sinomenine is an active substance extracted from the traditional Chinese medicine Sinomenium acutum. Sinomenine has been shown to mediate a wide range of pharmacological actions and is known to possess good anti-inflammatory, immunosuppressive, antitumor, neuroprotective, antiarrhythmic and other pharmacological effects. Understanding the underlying mechanisms and the association between the targets and the pharmaceutical effects on different diseases is crucial to the discovery and design of new treatment strategies. In this review, we aim to give a systematic and comprehensive overview of the research progress of sinomenine over the past 20 years. We first describe the metabolism of sinomenine in vivo and then summarize the pharmacological actions of sinomenine on different diseases. Furthermore, the potential binding properties of sinomenine and the potential of developing new sinomenine-based drugs are also reviewed.

KeywordAnti-inflammatory Anticancer Depression Neuroprotection Oxidative Stress Sinomenine Traditional Chinese Medicine
DOI10.1111/bph.16267
URLView the original
Indexed BySCIE
Language英語English
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:001108830400001
PublisherWILEY, 111 RIVER ST, HOBOKEN 07030-5774, NJ
Scopus ID2-s2.0-85177735574
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Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorKo, Chung Nga; Tian, Tiantian; Yang, Chao
Affiliation1.State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China
2.Macao Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao
3.The International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen), Shenzhen, China
4.Center for Biological Science and Technology, Advanced Institute of Natural Sciences, Beijing Normal University at Zhuhai, Zhuhai, China
5.National Engineering Research Center For Marine Aquaculture, Institute of Innovation & Application, Zhejiang Ocean University, Zhoushan, China
Recommended Citation
GB/T 7714
Li, Dan,Zhong, Zhangfeng,Ko, Chung Nga,et al. From mundane to classic: Sinomenine as a multi-therapeutic agent[J]. British Journal of Pharmacology, 2023.
APA Li, Dan., Zhong, Zhangfeng., Ko, Chung Nga., Tian, Tiantian., & Yang, Chao (2023). From mundane to classic: Sinomenine as a multi-therapeutic agent. British Journal of Pharmacology.
MLA Li, Dan,et al."From mundane to classic: Sinomenine as a multi-therapeutic agent".British Journal of Pharmacology (2023).
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