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Diffusion Kinetic Model for Breast Cancer Segmentation in Incomplete DCE-MRI
Lv, Tianxu1; Liu, Yuan1; Miao, Kai3; Li, Lihua2; Pan, Xiang1,3
2023-10
Conference Name26th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2023
Source PublicationLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume14223 LNCS
Pages100-109
Conference DateOctober 8–12, 2023
Conference PlaceVancouver, BC, Canada
CountryCanada
PublisherSPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY
Abstract

Recent researches on cancer segmentation in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) usually resort to the combination of temporal kinetic characteristics and deep learning to improve segmentation performance. However, the difficulty in accessing complete temporal sequences, especially post-contrast images, hinders segmentation performance, generalization ability and clinical application of existing methods. In this work, we propose a diffusion kinetic model (DKM) that implicitly exploits hemodynamic priors in DCE-MRI and effectively generates high-quality segmentation maps only requiring pre-contrast images. We specifically consider the underlying relation between hemodynamic response function (HRF) and denoising diffusion process (DDP), which displays remarkable results for realistic image generation. Our proposed DKM consists of a diffusion module (DM) and segmentation module (SM) so that DKM is able to learn cancer hemodynamic information and provide a latent kinetic code to facilitate segmentation performance. Once the DM is pretrained, the latent code estimated from the DM is simply incorporated into the SM, which enables DKM to automatically and accurately annotate cancers with pre-contrast images. To our best knowledge, this is the first work exploring the relationship between HRF and DDP for dynamic MRI segmentation. We evaluate the proposed method for tumor segmentation on public breast cancer DCE-MRI dataset. Compared to the existing state-of-the-art approaches with complete sequences, our method yields higher segmentation performance even with pre-contrast images. The source code will be available on https://github.com/Medical-AI-Lab-of-JNU/DKM.

KeywordCancer Segmentation Dce-mri Deep Learning Denoising Diffusion Model Kinetic Representation
DOI10.1007/978-3-031-43901-8_10
URLView the original
Indexed ByCPCI-S
Language英語English
WOS Research AreaComputer Science ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectComputer Science, Software Engineering ; Computer Science, Theory & Methods ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:001109630700010
Scopus ID2-s2.0-85174676150
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Document TypeConference paper
CollectionFaculty of Health Sciences
Cancer Centre
DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding AuthorPan, Xiang
Affiliation1.School of Artificial Intelligence and Computer Science, Jiangnan University, Wuxi, 214122, China
2.Institute of Biomedical Engineering and Instrumentation, Hangzhou Dianzi University, Hangzhou, China
3.Cancer Center, Faculty of Health Sciences, University of Macau, Macao
Corresponding Author AffilicationCancer Centre
Recommended Citation
GB/T 7714
Lv, Tianxu,Liu, Yuan,Miao, Kai,et al. Diffusion Kinetic Model for Breast Cancer Segmentation in Incomplete DCE-MRI[C]:SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197 BERLIN, GERMANY, 2023, 100-109.
APA Lv, Tianxu., Liu, Yuan., Miao, Kai., Li, Lihua., & Pan, Xiang (2023). Diffusion Kinetic Model for Breast Cancer Segmentation in Incomplete DCE-MRI. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 14223 LNCS, 100-109.
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