| Residential College | false |
| Status | 已發表Published |
| Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion | |
Hsu, Sheng Kai1; Chon-Kit Chou2 ; Lin, I. Ling3; Chang, Wen Tsan4,5,6; Kuo, I. Ying1 ; Chiu, Chien Chih1,6,7,8
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| Source Publication | Cell Communication and Signaling
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| ISSN | 1478-811X |
| 2024-05 | |
| Abstract | Ubiquitination and deubiquitination are important forms of posttranslational modification that govern protein homeostasis. Deubiquitinating enzymes (DUBs), a protein superfamily consisting of more than 100 members, deconjugate ubiquitin chains from client proteins to regulate cellular homeostasis. However, the dysregulation of DUBs is reportedly associated with several diseases, including cancer. The tumor microenvironment (TME) is a highly complex entity comprising diverse noncancerous cells (e.g., immune cells and stromal cells) and the extracellular matrix (ECM). Since TME heterogeneity is closely related to tumorigenesis and immune evasion, targeting TME components has recently been considered an attractive therapeutic strategy for restoring antitumor immunity. Emerging studies have revealed the involvement of DUBs in immune modulation within the TME, including the regulation of immune checkpoints and immunocyte infiltration and function, which renders DUBs promising for potent cancer immunotherapy. Nevertheless, the roles of DUBs in the crosstalk between tumors and their surrounding components have not been comprehensively reviewed. In this review, we discuss the involvement of DUBs in the dynamic interplay between tumors, immune cells, and stromal cells and illustrate how dysregulated DUBs facilitate immune evasion and promote tumor progression. We also summarize potential small molecules that target DUBs to alleviate immunosuppression and suppress tumorigenesis. Finally, we discuss the prospects and challenges regarding the targeting of DUBs in cancer immunotherapeutics and several urgent problems that warrant further investigation. |
| Keyword | Cytotoxic t Cell (Ctl) Deubiquitinating Enzymes (Dubs) Immune Evasion Posttranslational Modification (Ptm) Regulatory t Cell (Treg) Tumor Microenvironment (Tme) Tumor-associated Macrophage (Tam) |
| Language | 英語English |
| DOI | 10.1186/s12964-024-01633-7 |
| URL | View the original |
| Volume | 22 |
| Issue | 1 |
| Pages | 259 |
| WOS ID | WOS:001215466500001 |
| WOS Subject | Cell Biology |
| WOS Research Area | Cell Biology |
| Indexed By | SCIE |
| Scopus ID | 2-s2.0-85192152695 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Review article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Kuo, I. Ying; Chiu, Chien Chih |
| Affiliation | 1.Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Science, University of Macau, 999078, Macao 3.Department of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung, 807, Taiwan 4.Division of General and Digestive Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan 5.Department of Surgery, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, 807, Taiwan 6.Center for Cancer Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, 807, Taiwan 7.Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung, 804, Taiwan 8.Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, 807, Taiwan |
| Recommended Citation GB/T 7714 | Hsu, Sheng Kai,Chon-Kit Chou,Lin, I. Ling,et al. Deubiquitinating enzymes: potential regulators of the tumor microenvironment and implications for immune evasion[J]. Cell Communication and Signaling, 2024, 22(1), 259. |
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