In recent years, tumor catalytic therapy based on nanozymes has attracted widespread attention. However, its application is limited by the tumor hypoxic microenvironment (TME). In this study, we developed oxygen-supplying magnetic bead nanozymes that integrate hemoglobin and encapsulate the photosensitizer curcumin, demonstrating reactive oxygen species (ROS)-induced synergistic breast cancer therapy. Fe₃O₄ magnetic bead-mediated catalytic dynamic therapy (CDT) generates hydroxyl radicals (˙OH) through the Fenton reaction in the tumor microenvironment. The Hb-encapsulated Fe₃O₄ magnetic beads can be co-loaded with the photosensitizer/chemotherapeutic agent curcumin (cur), resulting in Fe₃O₄-Hb@cur. Under hypoxic conditions, oxygen molecules are released from Fe₃O₄-Hb@cur to overcome the TME hypoxia, resulting in comprehensive effects favoring anti-tumor responses. Upon near-infrared (NIR) irradiation, Fe₃O₄-Hb@cur activates the surrounding molecular oxygen to generate a certain amount of singlet oxygen O), which is utilized for photodynamic therapy (PDT) in cancer treatment. Meanwhile, we validated that the O carried by Hb significantly enhances the intracellular ROS level, intensifying the catalytic therapy mediated by Fe₃O₄ magnetic beads and inflicting lethal damage to cancer cells, effectively inhibiting tumor growth. Therefore, significant in vivo synergistic therapeutic effects can be achieved through catalytic-photodynamic combination therapy.