A versatile sensing platform employing inorganic MoS nanoflowers and organic poly(3,4-ethylene dioxythiophene): poly (styrene sulfonate) (PEDOT:PSS) has been investigated to develop the resistive and capacitive force-sensitive devices. The microstructure of the sensing layer heightens the sensitivity and response time of the dual-mode pressure sensors by augmenting electron pathways and inner stress in response to mechanical stimuli. Consequently, the capacitive and resistive sensors exhibit sensitivities of 0.37 and 0.12 kPa, respectively, while demonstrating a remarkable response time of approximately 100 ms. Furthermore, it is noteworthy that the PEDOT:PSS layer exhibits excellent adhesion to polydimethylsiloxane (PDMS) substrates, which contributes to the development of highly robust force sensitive sensors capable of enduring more than 10000 loading/unloading cycles. The combination of MoS/PEDOT:PSS layers in these dual-mode sensors has shown promising results in detecting human joint movements and subtle physiological signals. Notably, the sensors have achieved a remarkable precision rate of 98% in identifying target objects. These outcomes underscore the significant potential of these sensors for integration into applications such as electronic skin and human-machine interaction.