| Residential College | false |
| Status | 已發表Published |
| Emerging anticancer potential and mechanisms of snake venom toxins: A review | |
| Guo, Xijun1; Fu, Yuanfeng1; Peng, Junbo1; Fu, Ying1; Dong, Shuai1; Ding, Ren Bo1,2; Qi, Xingzhu1; Bao, Jiaolin1,2 | |
| 2024-06-01 | |
| Source Publication | International Journal of Biological Macromolecules
 |
| ISSN | 0141-8130 |
| Volume | 269 |
| Abstract | Animal-derived venom, like snake venom, has been proven to be valuable natural resources for the drug development. Previously, snake venom was mainly investigated in its pharmacological activities in regulating coagulation, vasodilation, and cardiovascular function, and several marketed cardiovascular drugs were successfully developed from snake venom. In recent years, snake venom fractions have been demonstrated with anticancer properties of inducing apoptotic and autophagic cell death, restraining proliferation, suppressing angiogenesis, inhibiting cell adhesion and migration, improving immunity, and so on. A number of active anticancer enzymes and peptides have been identified from snake venom toxins, such as L-amino acid oxidases (LAAOs), phospholipase A2 (PLA), metalloproteinases (MPs), three-finger toxins (3FTxs), serine proteinases (SPs), disintegrins, C-type lectin-like proteins (CTLPs), cell-penetrating peptides, cysteine-rich secretory proteins (CRISPs). In this review, we focus on summarizing these snake venom-derived anticancer components on their anticancer activities and underlying mechanisms. We will also discuss their potential to be developed as anticancer drugs in the future. |
| Keyword | Angiogenesis Anticancer Cell proliferation Invasion and migration Programmed cell death Snake venom toxins |
| DOI | 10.1016/j.ijbiomac.2024.131990 |
| URL | View the original |
| Language | 英語English |
| Scopus ID | 2-s2.0-85192499001 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | University of Macau |
| Affiliation | 1.Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Collaborative Innovation Center of One Health, Hainan University, Haikou, 570228, China 2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, 999078, China |
| Recommended Citation GB/T 7714 | Guo, Xijun,Fu, Yuanfeng,Peng, Junbo,et al. Emerging anticancer potential and mechanisms of snake venom toxins: A review[J]. International Journal of Biological Macromolecules, 2024, 269. |
| APA | Guo, Xijun., Fu, Yuanfeng., Peng, Junbo., Fu, Ying., Dong, Shuai., Ding, Ren Bo., Qi, Xingzhu., & Bao, Jiaolin (2024). Emerging anticancer potential and mechanisms of snake venom toxins: A review. International Journal of Biological Macromolecules, 269. |
| MLA | Guo, Xijun,et al."Emerging anticancer potential and mechanisms of snake venom toxins: A review".International Journal of Biological Macromolecules 269(2024). |
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