| Residential College | false |
| Status | 已發表Published |
| Antibody Recognition of Human Epidermal Growth Factor Receptor-2 (HER2) Juxtamembrane Domain Enhances Anti-Tumor Response of Chimeric Antigen Receptor (CAR)-T Cells | |
Zhou, Guangyu1,2; Fu, Shengyu1; Zhang, Yunsen3; Li, Shuang4; Guo, Ziang1; Ouyang, Defang3 ; Ying, Tianlei5; Lu, Yinying4 ; Zhao, Qi1,2
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| 2024-06 | |
| Source Publication | Antibodies
 |
| ISSN | 2073-4468 |
| Volume | 13Issue:2Pages:45 |
| Abstract | Chimeric antigen receptor (CAR) T cell therapy shows promise in treating malignant tumors. However, the use of human epidermal growth factor receptor-2 (HER2) CAR-T cells carries the risk of severe toxicity, including cytokine release syndrome, due to their “on-target off-tumor” recognition of HER2. Enhancing the quality and functionality of HER2 CARs could greatly improve the therapeutic potential of CAR-T cells. In this study, we developed a novel anti-HER2 monoclonal antibody, Ab8, which targets domain III of HER2, distinct from the domain IV recognition of trastuzumab. Although two anti-HER2 mAbs induced similar levels of antibody-dependent cellular cytotoxicity, trastuzumab-based CAR-T cells exhibited potent antitumor activity against HER2-positive cancer cells. In conclusion, our findings provide scientific evidence that antibody recognition of the membrane-proximal domain promotes the anti-tumor response of HER2-specific CAR-T cells. |
| Keyword | Her2 Monoclonal Antibody Car-t Cell Trastuzumab |
| DOI | 10.3390/antib13020045 |
| URL | View the original |
| Indexed By | ESCI |
| Language | 英語English |
| WOS Research Area | Immunology |
| WOS Subject | Immunology |
| WOS ID | WOS:001254684500001 |
| Publisher | MDPI, ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND |
| Scopus ID | 2-s2.0-85197181721 |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Faculty of Health Sciences Institute of Chinese Medical Sciences Cancer Centre Institute of Translational Medicine DEPARTMENT OF BIOMEDICAL SCIENCES Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau |
| Corresponding Author | Lu, Yinying; Zhao, Qi |
| Affiliation | 1.Institute of Translational Medicine, Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa 999078, Macau SAR, China 2.MoE Frontiers Science Center for Precision Oncology, University of Macau, Taipa 999078, Macau SAR, China 3.Institute of Chinese Medical Sciences, University of Macau, Taipa 999078, Macau SAR, China; 4.The Fifth Medical Center of the PLA General Hospital, Beijing, 100036, China 5.MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology, Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Engineering Research Center for Synthetic Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China |
| First Author Affilication | Cancer Centre; University of Macau |
| Corresponding Author Affilication | Cancer Centre; University of Macau |
| Recommended Citation GB/T 7714 | Zhou, Guangyu,Fu, Shengyu,Zhang, Yunsen,et al. Antibody Recognition of Human Epidermal Growth Factor Receptor-2 (HER2) Juxtamembrane Domain Enhances Anti-Tumor Response of Chimeric Antigen Receptor (CAR)-T Cells[J]. Antibodies, 2024, 13(2), 45. |
| APA | Zhou, Guangyu., Fu, Shengyu., Zhang, Yunsen., Li, Shuang., Guo, Ziang., Ouyang, Defang., Ying, Tianlei., Lu, Yinying., & Zhao, Qi (2024). Antibody Recognition of Human Epidermal Growth Factor Receptor-2 (HER2) Juxtamembrane Domain Enhances Anti-Tumor Response of Chimeric Antigen Receptor (CAR)-T Cells. Antibodies, 13(2), 45. |
| MLA | Zhou, Guangyu,et al."Antibody Recognition of Human Epidermal Growth Factor Receptor-2 (HER2) Juxtamembrane Domain Enhances Anti-Tumor Response of Chimeric Antigen Receptor (CAR)-T Cells".Antibodies 13.2(2024):45. |
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