| Residential College | false |
| Status | 已發表Published |
| Title | Glycine tabacina Extract Alleviates Inflammatory Bowel Disease via NF-B, JNK and Nrf2 Signaling Pathways |
| Author | LIANG Yongkai 
|
| Subtype | 硕士Master |
| Thesis Advisor | Prof. HE CHENGWEI |
| Date Issued | 2024-06 |
| Degree Grantor | University of Macau |
| Place of Conferral | Taipa, Macau SAR |
| Degree Name | Master of Philosophy |
| Degree Discipline | Chinese Medicine |
| Keyword | Colitis Natural Herb Anti-inflammation Anti-oxidation |
| Abstract | Inflammatory Bowel Disease (IBD) is a disease caused by complex factors leading to the inflammation, fibrosis, fistula, and ulceration of colonic tissues throughout the intestinal track. Some of the major causes are genes, diets, pathogen infection leading to aberrant immune response, side effects of drugs and lifestyles. Symptoms of IBD includes weight loss, diarrhea, and occult bleeding which may lead to anemia and other diseases such as colorectal cancer. The disease cannot be fully cured as for now because many patients are tolerance to the drugs and there are side effects. In this study, we used an aqueous extract of a natural herb, Glycine tabacina (Labill.) Benth (GTE). It is a plant belongs to the bean family and distributed in China, South-East Asia, Australia, and Oceanic countries. The major active components in GTE are isoflavonoids such as daizein, genistein, and genenistin. Based on previous studies of GTE regulating signaling pathways in rheumatoid arthritis, nephritis, and osteoporosis are similar to IBD. Thus, we want to examine GTE with LPS and TNF- induced human colorectal adenocarcinoma cells (Caco 2) and DSS induced Balb/C mice. Through the in vitro and in vivo model, the anti-colitis effects of GTE were identified. GTE maintains the barrier function of intestinal cells through down regulating MMPs and pro-inflammatory cytokines in vivo by decreasing phosphorylation of proteins in NF-B and MAPK/JNK pathways. Oxidative stress in intestinal cells and tissues are down regulated since GTE was able to reduce the level of ROS through enhancing the protein expression of Nrf2 to increase the expression level of anti-oxidants, HO-1 and NQO1. GTE also have the same effects in DSS induced mice, the diseases activities and pathological sites in the colonic tissues are reduced in the presence of GTE treatment. GTE might become a cost effective Chinese traditional medicine for IBD alternative treatment. |
| Document Type | Thesis |
| Collection | University of Macau |
| Recommended Citation GB/T 7714 | LIANG Yongkai. Glycine tabacina Extract Alleviates Inflammatory Bowel Disease via NF-B, JNK and Nrf2 Signaling Pathways[D]. Taipa, Macau SAR, University of Macau, 2024. |
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| YongkaiLIANG master'（3104KB） | 学位论文 | 开放获取 | CC BY-NC-SA | View Download | ||
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