| Residential College | false |
| Patent Number | 2024103514848 |
| Status | 申請中 Pending |
| 一种负载 2-脱氧-D-葡萄糖和偶联抗 PD-L1 纳米抗体的免疫佐剂及其制备方法和应用 | |
| Year Issued | 2024 |
| 2024-03 | |
| Application Number | 2024103514848 |
ZHAO QI ; Dai Yeneng
| |
| Country | China |
| Subtype | 发明专利 Invention |
| Abstract | 本发明属于肿瘤免疫治疗技术领域，公开了一种负载2-脱氧-D-葡萄糖和偶联抗PD-L1纳米抗体的免疫佐剂及其制备方法和应用，具体公开了一种免疫佐剂，包括纳米颗粒和负载在所述纳米颗粒上的糖代谢抑制剂和免疫检查点抑制剂，所述纳米颗粒由近红外二区小分子和金属离子配位自组装而成。本发明提供的免疫佐剂能够通过主动靶向实现抗PD-L1抗体和2-脱氧-D-葡萄糖的肿瘤递送，同时可以阻断PD-1/PD-L1信号通路，实现ICB治疗。NIR-II光热治疗和铁死亡引发的适应性免疫进一步弥补和增强ICB治疗效果。 |
| Document Type | Patent |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Affiliation | University of Macau |
| Recommended Citation GB/T 7714 | ZHAO QI,Dai Yeneng. 一种负载 2-脱氧-D-葡萄糖和偶联抗 PD-L1 纳米抗体的免疫佐剂及其制备方法和应用. 2024103514848[P]. 2024-03-01. |
| APA | ZHAO QI., & Dai Yeneng 一种负载 2-脱氧-D-葡萄糖和偶联抗 PD-L1 纳米抗体的免疫佐剂及其制备方法和应用. |
| Files in This Item: | Download All | |||||
| File Name/Size | Publications | Version | Access | License | ||
| 2024103514848_一种负载2-（262KB） | 专利 | 开放获取 | CC BY-NC-SA | View Download | ||
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