| Residential College | false |
| Status | 已發表Published |
| The application of dendrimer-small RNA system to target renin-angiotensin system for cancer therapy | |
LEE TSZ ON 
| |
| 2023-10 | |
| Size of Audience | 50 |
| Type of Speaker | Invited Speaker and Session Chair |
| Abstract | Small-molecule agonists/antagonists designed to target these receptors face challenges associated with potent side effects and a lack of specificity. In contrast, small nucleic acid molecules present a distinctive opportunity to tackle so-called 'undruggable' targets, including a lot of G protein-coupled receptors (GPCRs). The activation of angiotensin receptor type I (AGTR1) stimulates the formation of ovarian cancer spheroids and peritoneal metastasis by augmenting lipid desaturation, thereby reducing endoplasmic reticulum stress. Since the Mas receptor (MAS1) has demonstrated its ability to counteract the AGTR1 pathway in the cardiovascular system, we hypothesis that the activation of MAS1 or the silencing of AGTR1 may effectively inhibit the progression and metastasis of cancer. In this study, we present groundbreaking findings demonstrating that small activating RNAs (saRNAs) are highly effective in modulating a GPCR for cancer treatment. Specifically, we have identified saRNAs that boost the expression of MAS1. When delivered via an amphiphilic dendrimer vector, these saRNAs lead to a substantial reduction in tumorigenesis and the hindrance of tumor progression in multiple types of cancer. Our research not only introduces a novel approach to cancer therapy by targeting the renin-angiotensin system but also opens a new avenue for addressing GPCRs and other previously considered 'undruggable' targets. |
| Source Publication | China-Belarus-Russia International Forum of Innovative Nanomedicine |
| Conference Date | 29-31 Oct, 2023 |
| Conference Place | Donghua University, Shanghai |
| Document Type | Presentation |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | LEE TSZ ON |
| Affiliation | Faculty of Health Sciences, University of Macau |
| Recommended Citation GB/T 7714 | LEE TSZ ON. The application of dendrimer-small RNA system to target renin-angiotensin system for cancer therapy[Z]. China-Belarus-Russia International Forum of Innovative Nanomedicine, 29-31 Oct, 2023. |
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