Targeting the phosphatidylglycerol lipid: an amphiphilic dendrimer as a promising antibacterial candidate

Residential College	false
Status	即將出版Forthcoming
	Targeting the phosphatidylglycerol lipid: an amphiphilic dendrimer as a promising antibacterial candidate
	Zhang Nian ; Dhumal Dinesh ; Kuo Shanny Hsuan ; Lew Shi Qian ; Patil Pankaj ; Taher Raleb ; Vaidya Sanika ; Galanakou Christina ; Elkihel Abdechakour ; Oh Myung Whan ; Chong Sook Yin ; Marson Domenico ; Zheng Jun ; Rouvinski Oleg ; Abolarin Williams ; Price Sabrina ; Lau Gee ; Lee, Leo Tsz On ; Peng Ling
	2024-08
Source Publication	Science Advances
Abstract	The rapid emergence and spread of multidrug-resistant bacterial pathogens require the development of antibacterial agents that are robustly effective while inducing no toxicity or resistance development. In this context, we designed and synthesized amphiphilic dendrimers as antibacterial candidates. We report the promising potent antibacterial activity shown by the amphiphilic dendrimer AD1b, composed of a long hydrophobic alkyl chain and a tertiary amine-terminated poly(amidoamine) (PAMAM) dendron, against a panel of Gram-negative bacteria, including multidrug-resistant Escherichia coli and Acinetobacter baumannii. More importantly, AD1b exhibited effective activity against drug-resistant bacterial infections in vivo. Mechanistic studies revealed that AD1b targeted the membrane phospholipids phosphatidylglycerol (PG) and cardiolipin (CL), leading to the disruption of the bacterial membrane and proton motive force, metabolic disturbance, leakage of cellular components, and ultimately cell death. Taken together, AD1b that specifically interacts with PG/CL in bacterial membranes support the use of small amphiphilic dendrimers as a promising strategy to target drug-resistant bacterial pathogens and address the global antibiotic crisis.
Indexed By	SCIE
Language	英語English
Funding Project	Angiotensin II biased ligand and G protein-coupled kinase 2 mediate beta-arrestin signaling to suppress ovarian cancer cell adhesion
Document Type	Journal article
Collection	University of Macau
Corresponding Author	Lau Gee; Lee, Leo Tsz On; Peng Ling
Affiliation	1.Cancer Centre, Faculty of Health Sciences, University of Macau 2.Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau
Recommended Citation GB/T 7714	Zhang Nian,Dhumal Dinesh,Kuo Shanny Hsuan,et al. Targeting the phosphatidylglycerol lipid: an amphiphilic dendrimer as a promising antibacterial candidate[J]. Science Advances, 2024.
APA	Zhang Nian., Dhumal Dinesh., Kuo Shanny Hsuan., Lew Shi Qian., Patil Pankaj., Taher Raleb., Vaidya Sanika., Galanakou Christina., Elkihel Abdechakour., Oh Myung Whan., Chong Sook Yin., Marson Domenico., Zheng Jun., Rouvinski Oleg., Abolarin Williams., Price Sabrina., Lau Gee., Lee, Leo Tsz On., & Peng Ling (2024). Targeting the phosphatidylglycerol lipid: an amphiphilic dendrimer as a promising antibacterial candidate. Science Advances.
MLA	Zhang Nian,et al."Targeting the phosphatidylglycerol lipid: an amphiphilic dendrimer as a promising antibacterial candidate".Science Advances (2024).

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