A Supramolecular Nanoprodrug for Prevention of Gallstone Formation

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	即將出版Forthcoming
	A Supramolecular Nanoprodrug for Prevention of Gallstone Formation
	Xiangjun Zhang; Xiaodi Yang; Yan Wang; Zhongping Xu; Sisi Yi; Tao Guo; Yue Liao; Xiyu Tang; Jianxiang Zhang; WANG RUIBING
	2024-04
Source Publication	Chinese Chemical Letters
Abstract	Cholelithiasis affects approximately 10%-20% of the adult population globally. And cholesterol accumulation and nucleation of cholesterol crystals are commonly recognized as the primary process in the initiation and progression of gallstones. Hydroxypropyl-β-cyclodextrin (HPCD) is a supramolecular host compound that can solubilize cholesterol, potentially serving as a preventative or therapeutic agent for cholelithiasis. However, we found that the administration of HPCD treatment did not impede the formation of gallstones in mice, mainly attributed to the pre-complexation of its cavity during the transition process. Here we synthesized a prodrug of HPCD and prepared a HPCD nanoparticle (HPCD-NP), which can be transported efficiently to the gallbladder through the hepatobiliary system following an intravenous injection. In the bile, the HPCD-NP degraded into free HPCD, bound to cholesterol crystals and gallstones within the gallbladder and effectively increased cholesterol solubilization, leading to gallstones regression. Given the established safety of both HPCD and cyclodextrin-based nanoparticles in numerous animal and human studies, HPCD-NP shows considerable promise for the prevention and treatment of human cholelithiasis.
Other Abstract	Upon intravenous administration, HPCD-NP could be transited into the bile duct via the hepatobiliary transport pathway and degrade into free HPCD, which subsequently solubilizes cholesterol and inhibits the gallstone formation.
Language	英語English
Publisher	Chinese Chemical Letters
Document Type	Journal article
Collection	Institute of Chinese Medical Sciences
Corresponding Author	Jianxiang Zhang; WANG RUIBING
Affiliation	Institute of Chinese Medical Sciences, and Department of Pharmaceutical Sciences, Faculty of Health Sciences, University of Macau, Macau SAR, 999078
Recommended Citation GB/T 7714	Xiangjun Zhang,Xiaodi Yang,Yan Wang,et al. A Supramolecular Nanoprodrug for Prevention of Gallstone Formation[J]. Chinese Chemical Letters, 2024.
APA	Xiangjun Zhang., Xiaodi Yang., Yan Wang., Zhongping Xu., Sisi Yi., Tao Guo., Yue Liao., Xiyu Tang., Jianxiang Zhang., & WANG RUIBING (2024). A Supramolecular Nanoprodrug for Prevention of Gallstone Formation. Chinese Chemical Letters.
MLA	Xiangjun Zhang,et al."A Supramolecular Nanoprodrug for Prevention of Gallstone Formation".Chinese Chemical Letters (2024).

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