| Residential College | false |
| Status | 已發表Published |
| An essential telomere binding protein regulating the transition from primary to secondary metabolism in Aspergillus nidulans | |
GUO SHUHUI ; LIU XIAOFENG; PARDESHI LAKHANSING; WONG KOON HO 
| |
| 2024-03 | |
| Conference Name | 32nd Fungal Genetics Conference |
| Conference Date | 12/03/2024 |
| Conference Place | Asilomar Conference Ground |
| Country | USA |
| Abstract | Fungi can produce a wide range of diverse secondary metabolites (SMs). These SMs are synthesized by specialized enzymes encoded by genes that are often organized into clusters located near the telomeres of chromosomes. The sub-telomeric arrangement is believed to facilitate gene silencing, preventing secondary metabolism during the active growth stage when the cell primarily focuses on primary metabolism for energy and macromolecule biosynthesis. Under nutrient limitation or during the stationary growth phase, the cell undergoes a transition from primary to secondary metabolism, producing SMs that are crucial for fungal survival in specific environmental niches. Although various global regulators of secondary metabolism and SM cluster- specific transcription factors have been identified, the molecular mechanism underlying the coordination between primary and secondary metabolisms remains unclear. In this study, we have identified a hitherto uncharacterized protein that binds to telomeres as well as numerous secondary metabolism genes of different SM biosynthetic gene clusters in Aspergillus nidulans. Transcription profiling analysis reveals the protein’s function as a transcriptional activator for the secondary metabolism genes. Interestingly, this protein also negatively regulates gene functions that are essential for the active growth stage, such as primary carbon and nitrogen metabolism, energy production, and nucleotide metabolism. Based on these findings, we propose that the telomere binding protein acts as a molecular switch, regulating the transition from primary to secondary metabolism. |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | WONG KOON HO |
| Affiliation | Faculty of Health Sciences, University of Macau |
| First Author Affilication | Faculty of Health Sciences |
| Corresponding Author Affilication | Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | GUO SHUHUI,LIU XIAOFENG,PARDESHI LAKHANSING,et al. An essential telomere binding protein regulating the transition from primary to secondary metabolism in Aspergillus nidulans[C], 2024. |
| APA | GUO SHUHUI., LIU XIAOFENG., PARDESHI LAKHANSING., & WONG KOON HO (2024). An essential telomere binding protein regulating the transition from primary to secondary metabolism in Aspergillus nidulans. . |
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