| Residential College | false |
| Status | 已發表Published |
| Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery | |
Jiali Chen1 ; Yiyang Li1; Xingping Quan1; Jinfen Chen1; Yan Han1; Li Yang2; Manfei Zhou1; Greta Seng Peng Mok1; Ruibing Wang1; Yonghua Zhao1 
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| 2025-08 | |
| Source Publication | Neural Regeneration Research
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| Volume | 20Issue:8Pages:2181-2198 |
| Abstract | Ischemic stroke is a secondary cause of mortality worldwide, imposing considerable medical and economic burdens on society. Extracellular vesicles, serving as natural nano-carriers for drug delivery, exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic stroke. However, the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery efficiency. By utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles, their delivery efficacy may be greatly improved. Furthermore, previous studies have indicated that microvesicles, a subset of large-sized extracellular vesicles, can transport mitochondria to neighboring cells, thereby aiding in the restoration of mitochondrial function post-ischemic stroke. Small extracellular vesicles have also demonstrated the capability to transfer mitochondrial components, such as proteins or deoxyribonucleic acid, or their sub-components, for extracellular vesicle-based ischemic stroke therapy. In this review, we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification methodologies. Given the complex facets of treating ischemic stroke, we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment process. Moreover, given the burgeoning interest in mitochondrial delivery, we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy. |
| DOI | 10.4103/NRR.NRR-D-24-00243 |
| Indexed By | SCIE |
| Language | 英語English |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | Institute of Chinese Medical Sciences |
| Corresponding Author | Yonghua Zhao |
| Affiliation | 1.University of Macau 2.Hunan Provincial People’s Hospital |
| First Author Affilication | University of Macau |
| Corresponding Author Affilication | University of Macau |
| Recommended Citation GB/T 7714 | Jiali Chen,Yiyang Li,Xingping Quan,et al. Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery[J]. Neural Regeneration Research, 2025, 20(8), 2181-2198. |
| APA | Jiali Chen., Yiyang Li., Xingping Quan., Jinfen Chen., Yan Han., Li Yang., Manfei Zhou., Greta Seng Peng Mok., Ruibing Wang., & Yonghua Zhao (2025). Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery. Neural Regeneration Research, 20(8), 2181-2198. |
| MLA | Jiali Chen,et al."Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke: a special outlook on mitochondrial delivery".Neural Regeneration Research 20.8(2025):2181-2198. |
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