| Residential College | false |
| Status | 已發表Published |
| Targeting glucose metabolism to develop anticancer treatments and therapeutic patents | |
Zhou Yan ; Guo Yizhen; TAM KIN YIP 
| |
| 2022-01 | |
| Source Publication | EXPERT OPINION ON THERAPEUTIC PATENTS
 |
| ISSN | 1354-3776 |
| Volume | 32Issue:4Pages:441-453 |
| Abstract | Introduction: One of the most distinctive hallmarks of cancer cells is increased glucose consumption for aerobic glycolysis, which is called the Warburg effect. In recent decades, extensive research has been carried out to exploit this famous phenomenon, trying to detect promising targetable vulnerabilities in altered metabolism to fight cancer. Targeting aberrant glucose metabolism can perturb cancer malignant proliferation and even induce programmed cell death. Areas covered: This review covered the recent patents which focused on targeting key glycolytic enzymes, including hexokinase, pyruvate dehydrogenase kinases, and lactate dehydrogenase for cancer treatment. Expert opinion: Compared with the conventional cancer treatment, specifically targeting the well-known Achilles heel, the Warburg effect has attracted considerable attention. Although there is still no single glycolytic agent for clinical cancer treatment, the combination of glycolytic inhibitor with conventional anticancer drugs or the combined use of multiple glycolytic inhibitors are being investigated extensively in recent years, which could emerge as attractive anticancer strategies |
| Keyword | Cancer Treatment Patent Cancer Glucose Metabolism Warburg Effect Hexokinase 2 (Hk2) Pyruvate Dehydrogenase Kinase (Pdk) Lactate Dehydrogenase a (Ldha) Glycolytic Inhibitor |
| DOI | 10.1080/13543776.2022.2027912 |
| URL | View the original |
| Indexed By | SCIE |
| Language | 英語English |
| Fulltext Access | |
| Citation statistics | |
| Document Type | Journal article |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | TAM KIN YIP |
| Affiliation | Faculty of Health Sciences |
| Recommended Citation GB/T 7714 | Zhou Yan,Guo Yizhen,TAM KIN YIP. Targeting glucose metabolism to develop anticancer treatments and therapeutic patents[J]. EXPERT OPINION ON THERAPEUTIC PATENTS, 2022, 32(4), 441-453. |
| APA | Zhou Yan., Guo Yizhen., & TAM KIN YIP (2022). Targeting glucose metabolism to develop anticancer treatments and therapeutic patents. EXPERT OPINION ON THERAPEUTIC PATENTS, 32(4), 441-453. |
| MLA | Zhou Yan,et al."Targeting glucose metabolism to develop anticancer treatments and therapeutic patents".EXPERT OPINION ON THERAPEUTIC PATENTS 32.4(2022):441-453. |
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