| Residential College | false |
| Status | 已發表Published |
| TET3 suppresses GATA6 to drive lipogenic subtype of pancreatic cancer | |
LIU SHUAI ; XIE RUIYU 
| |
| 2024-06-15 | |
| Size of Audience | 250 |
| Type of Speaker | poster presentation |
| Abstract | Pancreatic ductal adenocarcinoma (PDAC) manifests in three distinct metabolic subtypes: slow-proliferating, glycolytic, and lipogenic, as identified through comprehensive metabolite profiling. The expression of ten-eleven translocation 3 (TET3) in PDAC patients progressively increases from premalignant to malignant lesions. Through integrated transcriptomic and metabolomic analyses, we demonstrate that TET3 deficiency induces a phenotypic shift from the lipogenic to a slow-proliferating PDAC subtype. This transition is facilitated by the suppression of various fatty acid metabolic genes, thereby altering the ratio of saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs). Furthermore, TET3 upregulation leads to the decreased expression of GATA6, which in turn elevates TGF-β2 levels and promotes cancer cell invasion through an SMAD4-dependent manner. Collectively, our findings elucidate the molecular mechanisms by which TET3 drives malignancy, providing critical insights for the development of targeted therapeutic strategies in the treatment of pancreatic cancer. |
| Conference Date | 2024-06-15 |
| Conference Place | The 10th Macau Symposium on Biomedical Sciences, Macau |
| Document Type | Presentation |
| Collection | DEPARTMENT OF BIOMEDICAL SCIENCES |
| Corresponding Author | XIE RUIYU |
| Affiliation | Department of Biomedical Sciences, Faculty of Health Sciences, University of Macau, Macau SAR, China |
| Recommended Citation GB/T 7714 | LIU SHUAI,XIE RUIYU. TET3 suppresses GATA6 to drive lipogenic subtype of pancreatic cancer, 2024-06-15. |
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