DNA encapsulation reduces foreign body reaction of hPSC-derived insulin-producing cells transplanted into mice

UM > Faculty of Health Sciences > DEPARTMENT OF BIOMEDICAL SCIENCES

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Status	已發表Published
	DNA encapsulation reduces foreign body reaction of hPSC-derived insulin-producing cells transplanted into mice
	LIU RUI; WANG SHIWEN; XIE RUIYU
	2024-03-22
Size of Audience	300
Type of Speaker	poster presentation
Abstract	The transplantation of human pluripotent stem cell-derived insulin-producing cells (hPSC-IPCs) provides the potential to restore glycaemic control in patients with diabetes. Various implantable materials have enabled hPSC-IPCs encapsulation and glycaemic control in immune-deficient diabetic mice. Yet, immune-competent animals have experienced only transient cell-graft function due to severe foreign body reaction (FBR). There is a critical need for implantable materials that address this challenge to achieve long-term glycaemic control in immune-competent animals. DNA has recently been used as a promising material in cell encapsulation due to its inherent biocompatibility and excellent programmability. A natural DNA hydrogel microcapsule is developed to support graft function and mitigate FBR. The cell-encapsulating microcapsule was evaluated in vitro and in vivo to identify the cell viability, immune attack, and fibrous sedimentation. To our surprise, less cellular adhesion was observed on the surface of the DNA microcapsule. Next, we will investigate the mechanism and may try other DNA materials.
Conference Date	2024-03-22
Conference Place	The 8th Symposium on Biomedical Sciences for Students, Postdoctoral Fellows and Research Assistants , Macau
Document Type	Presentation
Collection	DEPARTMENT OF BIOMEDICAL SCIENCES
Corresponding Author	XIE RUIYU
Affiliation	Faculty of Health and Sciences, University of Macau, Macau SAR, China
Recommended Citation GB/T 7714	LIU RUI,WANG SHIWEN,XIE RUIYU. DNA encapsulation reduces foreign body reaction of hPSC-derived insulin-producing cells transplanted into mice, 2024-03-22.

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