| Residential College | true |
| Status | 即將出版Forthcoming |
| Artemisinins suppress melanoma recurrence and metastasis after radical surgery by inhibiting the c-KIT/PI3K/AKT signaling pathway | |
Zhiwei Zhou; ZHENG WENHUA 
| |
| 2024-06 | |
| Conference Name | The 10th Macau Symposium on Biomedical Science |
| Conference Date | 2024-06-13-15 |
| Conference Place | University of Macau,University Hall |
| Abstract | Malignant melanoma is one of the fatal diseases, with an increasing incidence rate all around the world. The standard therapy for melanoma is cancer radical surgery followed by chemotherapy and radiotherapy, but the effect is far from satisfactory and patients with these treatments still succumb to melanoma which appeals to a safer and more effective therapy. Artemisinin and its derivatives (termed Arts) are safe and effective anti-malarial drugs used in clinics for decades. Recently, Arts have been reported to present a wide range of bioactivities, including the anti-cancer effect. However, there is no information available regarding the effect of artemisinin on melanoma recurrence and metastasis after tumor excision. In the present study, we investigate the effect of artemisinin on melanoma recurrence and metastasis after tumor excision and its underlying mechanism. Our results showed that the application of Arts after tumor excision blocked the melanoma recurrence and metastasis and extended the life appetency of a host animal. RNA sequencing from both tissue and cell line samples identified several proteins, including c-KIT, as critical biomarkers in melanoma recurrence and metastasis regulated by Arts. Further mechanism studies involving transfection of overexpression plasmids and CRISP-Cas9 knockout experiments were carried out, which confirmed the effect of Arts on downregulating c-KIT and its downstream signaling targets PI3K/Akt and some EMT (Epithelial-Mesenchymal Transitions) biomarkers. These data suggested that Artemisinins suppressed melanoma recurrence and metastasis after radical surgery by inhibiting the c-KIT/PI3K/AKT signaling pathway. |
| Other Abstract | Supported by National Natural Science Foundation of China (32070969), The Science and Technology Development Fund, Macau SAR (File No. 0127/2019/A3, 0113/2018/A3 and 0038/2020/AMJ), The Guangdong Provincial Funding Committee for Basic and Applied Fundamental Research (2022-Natural Science Foundation), University of Macau (File No. MYRG2018-00134-FHS and MYRG2020-00158-FHS). |
| Keyword | Artemisinin Melanoma Post-surgery Model C-kit Akt |
| Document Type | Conference paper |
| Collection | DEPARTMENT OF PHARMACEUTICAL SCIENCES |
| Corresponding Author | ZHENG WENHUA |
| Recommended Citation GB/T 7714 | Zhiwei Zhou,ZHENG WENHUA. Artemisinins suppress melanoma recurrence and metastasis after radical surgery by inhibiting the c-KIT/PI3K/AKT signaling pathway[C], 2024. |
| APA | Zhiwei Zhou., & ZHENG WENHUA (2024). Artemisinins suppress melanoma recurrence and metastasis after radical surgery by inhibiting the c-KIT/PI3K/AKT signaling pathway. . |
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