Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?

doi:10.1007/s13577-024-01083-w

Residential College	false
Status	已發表Published
	Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?
	Wu, Yan 1,2; Chen, Dongfeng 3; Gao, Yang 3,4; Xu, Qinggang 3; Zhou, Yang 3; Ni, Zhong 3; Na, Manli 1,3,5
	2024-07-01
Source Publication	Human Cell
ISSN	0914-7470
Volume	37 Issue:4 Pages:931-943
Abstract	Immunosuppressive regulatory cells (IRCs) play important roles in negatively regulating immune response, and are mainly divided into myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs). Large numbers of preclinical and clinical studies have shown that inhibition or reduction of IRCs could effectively elevate antitumor immune responses. However, several studies also reported that excessive inhibition of IRCs function is one of the main reasons causing the side effects of cancer immunotherapy. Therefore, the reasonable regulation of IRCs is crucial for improving the safety and efficiency of cancer immunotherapy. In this review, we summarised the recent research advances in the cancer immunotherapy by regulating the proportion of IRCs, and discussed the roles of IRCs in regulating tumour immune evasion and drug resistance to immunotherapies. Furthermore, we also discussed how to balance the potential opportunities and challenges of using IRCs to improve the safety of cancer immunotherapies.
Keyword	Immunoregulatory cells Immunotherapy MDSCs Safety Tregs
DOI	10.1007/s13577-024-01083-w
URL	View the original
Language	英語English
Scopus ID	2-s2.0-85194756217
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science View Full-Text via Scopus
Citation statistics
Document Type	Journal article
Collection	University of Macau
Affiliation	1.Department of Burn and Plastic Surgery, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 210031, China 2.School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, 212013, China 3.School of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, 212013, China 4.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, 999078, Macao 5.International Genome Center, Jiangsu University, Zhenjiang, 301 Xuefu Road, Jiangsu, 212013, China
Recommended Citation GB/T 7714	Wu, Yan,Chen, Dongfeng,Gao, Yang,et al. Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?[J]. Human Cell, 2024, 37(4), 931-943.
APA	Wu, Yan., Chen, Dongfeng., Gao, Yang., Xu, Qinggang., Zhou, Yang., Ni, Zhong., & Na, Manli (2024). Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?. Human Cell, 37(4), 931-943.
MLA	Wu, Yan,et al."Immunosuppressive regulatory cells in cancer immunotherapy: restrain or modulate?".Human Cell 37.4(2024):931-943.

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