Xanthones from Garcinia mangostana protect oxidative injury in hepatocytes through upregulating SIRT3

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	Xanthones from Garcinia mangostana protect oxidative injury in hepatocytes through upregulating SIRT3
	Anqi Wang 1; Qianyu Liu 1; Yang Ye 2; Yitao Wang 1; LIN LIGEN1
	2015-11-18
Size of Audience	50
Type of Speaker	invited talk
Abstract	Bioactivity-guided fractionation of an ethanol-soluble extract from the pericarps of Garcinia mangostana, using tert-butyl hydroperoxide (t-BHP) induced oxidative damage in human normal hepatocytes (HL-7702), led to the identification of 10 known xanthones. Among them, γ-mangostin (γ-Man) exhibited the most potent activity to attenuate t-BHP induced hepatocytes injury. γ-Man significantly ameliorated t-BHP induced reactive oxygen species accumulation, mitochondrial membrane depolarization and cell nuclei morphology change in HL-7702 cells. t-BHP decreased intracellular key enzymes levels, including glutamate oxaloacetate transaminase and glutamate pyruvate transaminase, which was totally reversed by γ-Man. Moreover, γ-Man significantly decreased the level of lipid peroxidation and increased the levels of superoxide dismutase and reduced glutathione, resulting in alleviative oxidative stress. The above results suggest γ-Man as a potential hepatoprotective agent in t-BHP induced oxidative injury, which may benefit the further application of G. mangostana as healthy food.
Conference Place	Brisbane, Australia
Document Type	Presentation
Collection	Institute of Chinese Medical Sciences
Corresponding Author	LIN LIGEN
Affiliation	1.University of Macau 2.Shanghai Institute of Materia Medica
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Anqi Wang,Qianyu Liu,Yang Ye,et al. Xanthones from Garcinia mangostana protect oxidative injury in hepatocytes through upregulating SIRT3

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