α-Mangostin protects against age-associated metabolic disorders targeting adipose tissue inflammation

UM > Institute of Chinese Medical Sciences

Residential College	false
Status	已發表Published
	α-Mangostin protects against age-associated metabolic disorders targeting adipose tissue inflammation
	Li Dan; Liu Qianyu; LIN LIGEN
	2018
Size of Audience	80
Type of Speaker	invited talk
Abstract	Obesity and its related metabolic disorders are highly prevalent in the elderly individuals. Low-grade chronic adipose tissue inflammation contributes to the onset and development of age-related insulin resistance and type 2 diabetes. α-Mangostin (α-Man) is an anti-inflammatory xanthone from Garcinia mangostana. The present study was designed to verify the hypothesis that α-Man could alleviate adipose tissue inflammation to mitigate age-related metabolic disorders. α-Man suppressed lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 macrophages, and tumor necrosis factor α-mediated inflammation in 3T3-L1 adipocytes, through inhibiting the mitogen-activated protein kinases and nuclear factor-κB activation. In cell co-culture system, α-Man blocked RAW264.7 macrophages migration towards 3T3-L1 adipocytes. Furthermore, α-Man prevented mice from LPS-induced acute adipose tissue inflammation by reducing pro-inflammatory cytokines and chemokines expressions and inhibiting macrophages migration into adipose tissue and the pro-inflammatory polarization of macrophages. In a cohort of young (3-month) and old (18‒20-month) mice, α-Man obviously mitigated age-associated adiposity, hyperlipidemia and insulin resistance. α-Man alleviated age-related adipose tissue inflammation by reducing macrophage infiltration and pro-inflammatory polarization in adipose tissue. Moreover, α-Man reduced liver lipotoxicity through suppressing the secretion of microRNA-155-5p from macrophages. The above results demonstrated that α-Man might represent a novel candidate to treat aging-related metabolic disorders targeting adipose tissue inflammation.
Source Publication	International Conference on Medicinal Plants and Bioeconomy (ICMPB) & The 1st Sino-CPLP Symposium on Natural Products and Biodiversity Resources (SNPBR)
Conference Place	Macao, China
Document Type	Presentation
Collection	Institute of Chinese Medical Sciences
Corresponding Author	LIN LIGEN
Affiliation	University of Macau
First Author Affilication	University of Macau
Recommended Citation GB/T 7714	Li Dan,Liu Qianyu,LIN LIGEN. α-Mangostin protects against age-associated metabolic disorders targeting adipose tissue inflammation[Z]. International Conference on Medicinal Plants and Bioeconomy (ICMPB) & The 1st Sino-CPLP Symposium on Natural Products and Biodiversity Resources (SNPBR)

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